Evidence map›Paper›PMID 26639346›Full record

ArticleNature communications2015

Ontogeny of the maxilla in Neanderthals and their ancestors.

Rodrigo S Lacruz, Timothy G Bromage, Paul O'Higgins, Juan-Luis Arsuaga, Chris Stringer, Ricardo Miguel Godinho, Johanna Warshaw, Ignacio Martínez, Ana Gracia-Tellez, José María Bermúdez de Castro and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Shaping the human face: Periosteal bone modeling across ontogeny.Anatomical record (Hoboken, N.J. : 2007) · 2026
    Review
  2. Article
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  8. The evolutionary history of the human face.Nature ecology & evolution · 2019
    Review
  9. Article
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  11. Article
  12. Article
  13. Article
  14. The origin and evolution of Homo sapiens.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rodrigo S LacruzDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry; and NYCEP, New York City, New York, USA.
Timothy G BromageDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry; and NYCEP, New York City, New York, USA.
Paul O'HigginsCentre for Anatomical and Human Sciences, Department of Archaeology and Hull York Medical School, University of York, York, UK.
Juan-Luis ArsuagaUniversidad Complutense de Madrid-Instituto Carlos III (UCM-ISCIII), Centro de Investigacion de la Evolucion y Comportamiento Humanos, Madrid, Spain.
Chris StringerDepartment of Earth Sciences, Natural History Museum, London, UK.ORCID http://orcid.org/0000-0002-9183-7337
Ricardo Miguel GodinhoCentre for Anatomical and Human Sciences, Department of Archaeology and Hull York Medical School, University of York, York, UK.ORCID http://orcid.org/0000-0003-0107-9577
Johanna WarshawDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry; and NYCEP, New York City, New York, USA.
Ignacio MartínezDepartment de Ciencias de la Vida, Universidad de Alcalá, Alcalá de Henares, Spain.
Ana Gracia-TellezDepartment Geología, Geografía y Medio Ambiente, Fac. de Biología, Ciencias Ambientales y Química, Universidad de Alcalá, Madrid, Spain.
José María Bermúdez de CastroCentro Nacional de Investigacion sobre la Evolucion Humana, Burgos, Spain.
Eudald CarbonellInstitut Català de Paleoecologia Humana i Evolució Social, Tarragona, Spain.

Funding

Calcium Regulation and Oral HealthR00DE022799 · NIDCR · NEW YORK UNIVERSITY · PI LACRUZ, RODRIGO S. · 2014 to 2016
$728k
CALCIUM REGULATION IN ORAL HEALTHK99DE022799 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LACRUZ, RODRIGO S. · 2012 to 2013
$214k
NIDCR NIH HHS K99 DE022799NIDCR NIH HHS R00 DE022799
6 · The paper itself

Abstract

Neanderthals had large and projecting (prognathic) faces similar to those of their putative ancestors from Sima de los Huesos (SH) and different from the retracted modern human face. When such differences arose during development and the morphogenetic modifications involved are unknown. We show that maxillary growth remodelling (bone formation and resorption) of the Devil's Tower (Gibraltar 2) and La Quina 18 Neanderthals and four SH hominins, all sub-adults, show extensive bone deposition, whereas in modern humans extensive osteoclastic bone resorption is found in the same regions. This morphogenetic difference is evident by ∼5 years of age. Modern human faces are distinct from those of the Neanderthal and SH fossils in part because their postnatal growth processes differ markedly. The growth remodelling identified in these fossil hominins is shared with Australopithecus and early Homo but not with modern humans suggesting that the modern human face is developmentally derived.

Indexed as

AnimalsChildFossilsHominidaeHumansMaleMaxillaNeanderthals

Identifiers

PMID26639346
PMCPMC4686851

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.