ArticleLeukemia2016
Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia.
Open access · hybridAbstract readLetter
In one paragraph
Article in Leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 58 citations in OpenAlex.
- Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development.Cell reports · 2026Article
- Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia.Leukemia · 2025Article
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- Article
- Article
- YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity.Nature communications · 2024Article
- Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy.Cancer metastasis reviews · 2024Review
- Review
- Review
- IKAROS in Acute Leukemia: A Positive Influencer or a Mean Hater?International journal of molecular sciences · 2023Review
- Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation.EMBO reports · 2022Article
- Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents.Nucleic acids research · 2022Article
- Article
- Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications.Stem cell reviews and reports · 2022Review
- High efficacy of azacitidine combined with homoharringtonine, idarubicin, and cytarabine in newly diagnosed patients with AML: A single arm, phase 2 trial.Frontiers in oncology · 2022Article
- Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition.Molecular and cellular biology · 2021Article
- Epigenetic Control of Infant B Cell Precursor Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2021Review
- Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia.Cancers · 2021Article
- Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.International journal of molecular sciences · 2021Article
- Ikaros Proteins in Tumor: Current Perspectives and New Developments.Frontiers in molecular biosciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
C SongDepartment of Pediatrics, Pennsylvania State University Medical College, Hershey, PA, USA.
X PanDepartment of Pediatrics, Pennsylvania State University Medical College, Hershey, PA, USA.
Z GeDepartment of Pediatrics, Pennsylvania State University Medical College, Hershey, PA, USA.
C GowdaDepartment of Pediatrics, Pennsylvania State University Medical College, Hershey, PA, USA.
Y DingDepartment of Pediatrics, Pennsylvania State University Medical College, Hershey, PA, USA.
H LiDepartment of Pediatrics, Pennsylvania State University Medical College, Hershey, PA, USA.
Z LiDepartment of Pediatrics, Pennsylvania State University Medical College, Hershey, PA, USA.
G YochumDepartment of Biochemistry and Molecular Biology, Pennsylvania State University Medical College, Hershey, PA, USA.
M MuschenUniversity of California San Francisco, San Francisco, CA, USA.
Q LiDepartment of Statistics, Pennsylvania State University, University Park, State College, PA, USA.
K J PayneDepartment of Pathology and Human Anatomy and Center for Health Disparities and Molecular Medicine, Loma Linda University, Loma Linda, CA, USA.
S DovatDepartment of Pediatrics, Pennsylvania State University Medical College, Hershey, PA, USA.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · USLoma Linda University · USUniversity of California, San Francisco · US
Funding
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7MPenn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1MMetabolic gatekeepers in B-cell malignanciesR35CA197628 · NCI · YALE UNIVERSITY · PI Markus Müschen · 2016 to 2026
$11.7MNIH-LLU Initiative for Maximizing Student DiversityR25GM060507 · NIGMS · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2001 to 2022
$11.3MResearch Training/Education CoreP20MD006988 · NIMHD · LOMA LINDA UNIVERSITY · PI CASIANO, CARLOS A. · 2012 to 2016
$6.2MTargeted activation of autoimmune checkpoints in B cell malignanciesR01CA157644 · NCI · YALE UNIVERSITY · PI Markus Müschen · 2011 to 2026
$5.7MPENN STATE CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033184 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2011 to 2011
$4.5MStatistical methods for improving reproducibility and utility of sequencing dataR01GM109453 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI LI, QUNHUA · 2013 to 2022
$2.3MThe Role of Zinc Finger Genes in LeukemogenesisR01HL095120 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI DOVAT, SINISA · 2009 to 2013
$1.8MXenograft Model to Study Impact of CRLF2-Ligand in Hispanic Childhood B-ALLR21CA162259 · NCI · LOMA LINDA UNIVERSITY · PI PAYNE, KIMBERLY J · 2012 to 2013
$346kCancer Research UK 18131NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR002014NCI NIH HHS R01 CA157644NCI NIH HHS R21 CA162259NCI NIH HHS R35 CA197628NCRR NIH HHS UL1 RR033184NHLBI NIH HHS R01 HL095120NIGMS NIH HHS R01 GM109453NIGMS NIH HHS R25 GM060507NIMHD NIH HHS P20 MD006988
Abstract
PubMed holds no abstract for this paper.
Indexed as
Epigenesis, GeneticCasein Kinase IIGene Expression Regulation, NeoplasticHistone Deacetylase 1HumansIkaros Transcription FactorPrecursor B-Cell Lymphoblastic Leukemia-LymphomaCasein Kinase IIHDAC1 protein, humanHistone Deacetylase 1Ikaros Transcription FactorIKZF1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.