ArticleScientific reports2015
Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Modeling mammalian meiosis with pluripotent stem cells: progress and challenges.Clinical epigenetics · 2026Review
- Epigenetic regulation of reprogramming and pluripotency: insights from histone modifications and their implications for cancer stem cell therapies.Frontiers in cell and developmental biology · 2025Review
- Comparison of Nucleosome Landscapes Between Porcine Embryonic Fibroblasts and GV Oocytes.Animals : an open access journal from MDPI · 2024Article
- Spatial distribution of maternal factors in pig mature oocytes.Animal biotechnology · 2024Article
- Repetitive Sequence Stability in Embryonic Stem Cells.International journal of molecular sciences · 2024Review
- Review
- Metabolic control of induced pluripotency.Frontiers in cell and developmental biology · 2023Review
- Epigenetics, Enhancer Function and 3D Chromatin Organization in Reprogramming to Pluripotency.Cells · 2022Review
- Chromatin accessibility dynamics during cell fate reprogramming.EMBO reports · 2021Review
- Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334.Scientific reports · 2020Article
- An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis.Nature communications · 2019Article
- Conserved regulation of RNA processing in somatic cell reprogramming.BMC genomics · 2019Article
- Binding of HMGN proteins to cell specific enhancers stabilizes cell identity.Nature communications · 2018Article
- PCGF5 is required for neural differentiation of embryonic stem cells.Nature communications · 2018Article
- Small molecules for reprogramming and transdifferentiation.Cellular and molecular life sciences : CMLS · 2017Review
- Dynamic Reorganization of Nucleosome Positioning in Somatic Cells after Transfer into Porcine Enucleated Oocytes.Stem cell reports · 2017Article
- Ploidy-dependent changes in the epigenome of symbiotic cells correlate with specific patterns of gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genome-scale identification of nucleosome organization by using 1000 porcine oocytes at different developmental stages.PloS one · 2017Article
- Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications.Stem cell reviews and reports · 2016Review
- The Maternal Effect Genes UTX and JMJD3 Play Contrasting Roles in Mus musculus Preimplantation Embryo Development.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleosome positioning and histone modification play a critical role in gene regulation, but their role during reprogramming has not been fully elucidated. Here, we determined the genome-wide nucleosome coverage and histone methylation occupancy in mouse embryonic fibroblasts (MEFs), induced pluripotent stem cells (iPSCs) and pre-iPSCs. We found that nucleosome occupancy increases in promoter regions and decreases in intergenic regions in pre-iPSCs, then recovers to an intermediate level in iPSCs. We also found that nucleosomes in pre-iPSCs are much more phased than those in MEFs and iPSCs. During reprogramming, nucleosome reorganization and histone methylation around transcription start sites (TSSs) are highly coordinated with distinctively transcriptional activities. Bivalent promoters gradually increase, while repressive promoters gradually decrease. High CpG (HCG) promoters of active genes are characterized by nucleosome depletion at TSSs, while low CpG (LCG) promoters exhibit the opposite characteristics. In addition, we show that vitamin C (VC) promotes reorganizations of canonical, H3K4me3- and H3K27me3-modified nucleosomes on specific genes during transition from pre-iPSCs to iPSCs. These data demonstrate that pre-iPSCs have a more open and phased chromatin architecture than that of MEFs and iPSCs. Finally, this study reveals the dynamics and critical roles of nucleosome positioning and chromatin organization in gene regulation during reprogramming.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.