Evidence map›Paper›PMID 26639103›Full record

ArticleAdvanced healthcare materials2016

Photocleavable Hydrogels for Light-Triggered siRNA Release.

Cong Truc Huynh, Minh Khanh Nguyen, Gulen Yesilbag Tonga, Lionel Longé, Vincent M Rotello, Eben Alsberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Millimeter-Scale Dual-Opposing RNA-Gradient Hydrogel for Interfacial Gene Silencing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. On-Demand Chemically Degradable Hydrogels for Biological Applications.Chembiochem : a European journal of chemical biology · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Light: A Magical Tool for Controlled Drug Delivery.Advanced functional materials · 2020
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cong Truc Huynh *Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Minh Khanh Nguyen *Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Gulen Yesilbag Tonga *Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Lionel LongéDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Eben AlsbergDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

Funding

Driving Tissue Formation by Inductive Stem Cell Sheet TechnologyR01AR063194 · NIAMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALSBERG, EBEN · 2012 to 2016
$1.7M
Intracellular Host-Guest Activation of Nanoparticle TherapeuticsR01EB014277 · NIBIB · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2012 to 2014
$1.0M
Controlled, Sustained Delivery of siRNA to hMSCs for Enhanced Bone RegenerationR56DE022376 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI ALSBERG, EBEN · 2012 to 2012
$346k
NIAMS NIH HHS R01 AR063194NIAMS NIH HHS R01AR063194NIBIB NIH HHS EB014277NIBIB NIH HHS R01 EB014277NIDCR NIH HHS R56 DE022376NIDCR NIH HHS R56DE022376
6 · The paper itself

Abstract

A photocleavable hydrogel system for on-demand delivery of genetic material is reported. The release of short interfering RNAs can be triggered by the application of UV light without any loss in bioactivity. This approach provides a promising external stimulus-based nucleic acid delivery platform for applications in disease therapeutics and tissue regeneration.

Indexed as

Gene Transfer TechniquesHumansHydrogelsLightNucleic AcidsRegenerationRNA, Small InterferingTissue EngineeringHydrogelsNucleic AcidsRNA, Small Interferingcontrolled releaseon-demand releasephotolabile hydrogelssiRNAUV-controllable release

Identifiers

PMID26639103
PMCPMC4755586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.