ArticleScientific reports2015
Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The relevance of acid sphingomyelinase as a potential target for therapeutic intervention in hepatic disorders: current scenario and anticipated trends.Archives of toxicology · 2023Review
- The transcriptomic signature of responses to larval crowding in Drosophila melanogaster.Insect science · 2023Article
- Article
- Ceramides in Parkinson's Disease: From Recent Evidence to New Hypotheses.Frontiers in neuroscience · 2019Review
- The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy.Frontiers in cell and developmental biology · 2019Article
- Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.Scientific reports · 2018Article
- An integrative omics approach to unravel toxicity mechanisms of environmental chemicals: effects of a formulated herbicide.Scientific reports · 2018Article
- Impact ofInternational journal of molecular sciences · 2018Review
- Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide.Cell death & disease · 2018Article
- Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy.Cell reports · 2018Article
- Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in aFrontiers in molecular neuroscience · 2018Article
- Lipid metabolic perturbation is an early-onset phenotype in adultMolecular biology of the cell · 2017Article
- Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs.Neuromolecular medicine · 2016Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Sphingolipid metabolites are involved in the regulation of autophagy, a degradative recycling process that is required to prevent neuronal degeneration. Drosophila blue cheese mutants neurodegenerate due to perturbations in autophagic flux, and consequent accumulation of ubiquitinated aggregates. Here, we demonstrate that blue cheese mutant brains exhibit an elevation in total ceramide levels; surprisingly, however, degeneration is ameliorated when the pool of available ceramides is further increased, and exacerbated when ceramide levels are decreased by altering sphingolipid catabolism or blocking de novo synthesis. Exogenous ceramide is seen to accumulate in autophagosomes, which are fewer in number and show less efficient clearance in blue cheese mutant neurons. Sphingolipid metabolism is also shifted away from salvage toward de novo pathways, while pro-growth Akt and MAP pathways are down-regulated, and ER stress is increased. All these defects are reversed under genetic rescue conditions that increase ceramide generation from salvage pathways. This constellation of effects suggests a possible mechanism whereby the observed deficit in a potentially ceramide-releasing autophagic pathway impedes survival signaling and exacerbates neuronal death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.