ReviewCritical reviews in oncology/hematology2016
Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb).
Review in Critical reviews in oncology/hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- 3D-printed intelligent photothermal conversion NbMaterials today. Bio · 2025Article
- Elemental biomapping of human tissues suggests toxic metals such as mercury play a role in the pathogenesis of cancer.Frontiers in oncology · 2024Article
- Transition metals in angiogenesis - A narrative review.Materials today. Bio · 2023Review
- Photophysical characterization and in vitro anti-leishmanial effect of 5,10,15,20-tetrakis(4-fluorophenyl) porphyrin and the metal (Zn(II), Sn(IV), Mn(III) and V(IV)) derivatives.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Multivariate Investigation of Toxic and Essential Metals in the Serum from Various Types and Stages of Colorectal Cancer Patients.Biological trace element research · 2022Article
- An Updated Review on Properties and Indications of Calcium Silicate-Based Cements in Endodontic Therapy.International journal of dentistry · 2022Review
- Influence of Conventional or Invisalign Orthodontic Treatment on Mineral and Trace Element Salivary Levels: Longitudinal Study with Total Reflection X-ray Fluorescence.Biological trace element research · 2021Article
- Silicon Oxynitrophosphide Nanoscale Coating Enhances Antioxidant Marker-Induced Angiogenesis During in vivo Cranial Bone-Defect Healing.JBMR plus · 2021Article
- Article
- Nanotechnology for angiogenesis: opportunities and challenges.Chemical Society reviews · 2020Review
- 3D Bioprinting for Vascularized Tissue-Engineered Bone Fabrication.Materials (Basel, Switzerland) · 2020Review
- NdInternational journal of nanomedicine · 2020Article
- The Comparison of the Plasma Levels of the Lead Element in Patients with Gastrointestinal Cancers and Healthy Individuals.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children's Study (JECS).Environmental health and preventive medicine · 2019Article
- Functionalized biochar-supported magnetic MnFeRSC advances · 2018Article
- The effect of subacute lead exposure on selected blood inflammatory biomarkers and angiogenetic factors.Journal of occupational health · 2018Article
- Hydrogel Arrays and Choroidal Neovascularization Models for Evaluation of Angiogenic Activity of Vital Pulp Therapy Biomaterials.Journal of endodontics · 2018Article
- Nuclear receptor and VEGF pathways for gene-blood lead interactions, on bone mineral density, in Korean smokers.PloS one · 2018Article
- Improved in vitro angiogenic behavior on anodized titanium dioxide nanotubes.Journal of nanobiotechnology · 2017Article
- Calcium silicate-based cements and functional impacts of various constituents.Dental materials journal · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many essential elements exist in nature with significant influence on human health. Angiogenesis is vital in developmental, repair, and regenerative processes, and its aberrant regulation contributes to pathogenesis of many diseases including cancer. Thus, it is of great importance to explore the role of these elements in such a vital process. This is third in a series of reviews that serve as an overview of the role of inorganic elements in regulation of angiogenesis and vascular function. Here we will review the roles of titanium, lithium, cerium, arsenic, mercury, vanadium, niobium, and lead in these processes. The roles of other inorganic elements in angiogenesis were discussed in part I (N, Fe, Se, P, Au, and Ca) and part II (Cr, Si, Zn, Cu, and S) of these series. The methods of exposure, structure, mechanisms, and potential activities of these elements are briefly discussed. An electronic search was performed on the role of these elements in angiogenesis from January 2005 to April 2014. These elements can promote and/or inhibit angiogenesis through different mechanisms. The anti-angiogenic effect of titanium dioxide nanoparticles comes from the inhibition of angiogenic processes, and not from its toxicity. Lithium affects vasculogenesis but not angiogenesis. Nanoceria treatment inhibited tumor growth by inhibiting angiogenesis. Vanadium treatment inhibited cell proliferation and induced cytotoxic effects through interactions with DNA. The negative impact of mercury on endothelial cell migration and tube formation activities was dose and time dependent. Lead induced IL-8 production, which is known to promote tumor angiogenesis. Thus, understanding the impact of these elements on angiogenesis will help in development of new modalities to modulate angiogenesis under various conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.