ArticleScientific reports2015
A synthetic modular approach for modeling the role of the 3D microenvironment in tumor progression.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 3DACS biomaterials science & engineering · 2023Pooled it
- The hypoxic and acidic microenvironment created by GelMA hydrogels enhances the stem-like characteristics of lung cancer cells by inhibiting the MAPK signaling pathway.Molecular and cellular biochemistry · 2026Article
- Designing the matrix: extracellular matrix-informed strategies for bioengineered cancer models.Frontiers in bioengineering and biotechnology · 2026Review
- A soft-stiff patterned bioengineering model reveals kinase pathways driving directional cell migration in pulmonary arterial hypertension.Biomaterials science · 2025Article
- Making In Vitro Tumor Models Whole Again.Advanced healthcare materials · 2023Review
- Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy.Gels (Basel, Switzerland) · 2022Review
- Review
- Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy.Cancers · 2021Article
- Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics.iScience · 2021Review
- Matrix Stiffness Modulates Patient-Derived Glioblastoma Cell Fates in Three-Dimensional Hydrogels.Tissue engineering. Part A · 2021Article
- Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic Hydrogels.Gels (Basel, Switzerland) · 2021Review
- A comparative study of brain tumor cells from different age and anatomical locations using 3D biomimetic hydrogels.Acta biomaterialia · 2020Article
- Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems.Biosensors · 2020Review
- Linkage Groups within Thiol-Ene Photoclickable PEG Hydrogels Control In Vivo Stability.Advanced healthcare materials · 2019Article
- Biomimetic Designer Scaffolds Made of D,L-Lactide-Tissue engineering. Part B, Reviews · 2019Review
- Evaluation of PEG-based hydrogel influence on estrogen receptor driven responses in MCF7 breast cancer cells.ACS biomaterials science & engineering · 2019Article
- Tissue engineering the cancer microenvironment-challenges and opportunities.Biophysical reviews · 2018Review
- Comparative cytocompatibility of multiple candidate cell types to photoencapsulation in PEGNB/PEGDA macroscale or microscale hydrogels.Biomedical materials (Bristol, England) · 2018Article
- Multicellular tumor invasion and plasticity in biomimetic materials.Biomaterials science · 2017Review
- On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks.Biomaterials · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Here, we demonstrate the flexibility of peptide-functionalized poly(ethylene glycol) (PEG) hydrogels for modeling tumor progression. The PEG hydrogels were formed using thiol-ene chemistry to incorporate a matrix metalloproteinase-degradable peptide crosslinker (KKCGGPQG↓IWGQGCKK) permissive to proteolytic remodeling and the adhesive CRGDS peptide ligand. Tumor cell function was investigated by culturing WM239A melanoma cells on PEG hydrogel surfaces or encapsulating cells within the hydrogels, and either as monocultures or indirect (non-contact) cocultures with primary human dermal fibroblasts (hDFs). WM239A cluster size and proliferation rate depended on the shear elastic modulus for cells cultured on PEG hydrogels, while growth was inhibited by coculture with hDFs regardless of hydrogel stiffness. Cluster size was also suppressed by hDFs for WM239A cells encapsulated in PEG hydrogels, which is consistent with cells seeded on top of hydrogels. Notably, encapsulated WM239A clusters and single cells adopted invasive phenotypes in the hDF coculture model, which included single cell and collective migration modes that resembled invasion from human melanoma patient-derived xenograft tumors encapsulated in equivalent PEG hydrogels. Our combined results demonstrate that peptide-functionalized PEG hydrogels provide a useful platform for investigating aspects of tumor progression in 2D and 3D microenvironments, including single cell migration, cluster growth and invasion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.