Trial reportObesity (Silver Spring, Md.)2016
Weight loss on low-fat vs. low-carbohydrate diets by insulin resistance status among overweight adults and adults with obesity: A randomized pilot trial.
Trial report in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01661426 (Weight Loss Diet Study), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Weight Loss Diet Study: Low Carbohydrate vs. Low Fat and Insulin Resistance Status
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effects of carbohydrate-restricted diets and macronutrient replacements on cardiovascular health and body composition in adults: a meta-analysis of randomized trials.The American journal of clinical nutrition · 2025Pooled it
- Exploring avocado consumption and health: a scoping review and evidence map.Frontiers in nutrition · 2025Pooled it
- The Effect of Low-Fat and Low-Carbohydrate Diets on Weight Loss and Lipid Levels: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Pooled it
- The impact of a low-carbohydrate (vs. low-fat) diet on fat mass loss in African American women is modulated by insulin sensitivity.Obesity (Silver Spring, Md.) · 2025Trial
- Switching diets after 6-months does not result in renewed weight loss: a secondary analysis of a 12-month crossover randomized trial.Scientific reports · 2024Trial
- The Personalized Nutrition Study (POINTS): evaluation of a genetically informed weight loss approach, a Randomized Clinical Trial.Nature communications · 2023Trial
- Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study.International journal of obesity (2005) · 2023Trial
- Trial
- Trial
- Should carbohydrate-modified diets be the first option for weight loss in people with impaired glucose metabolism? A scoping review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024Article
- Low-Carbohydrate Diet is More Helpful for Weight Loss Than Low-Fat Diet in Adolescents with Overweight and Obesity: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Article
- Position statement on nutrition therapy for overweight and obesity: nutrition department of the Brazilian association for the study of obesity and metabolic syndrome (ABESO-2022).Diabetology & metabolic syndrome · 2023Review
- Optimization of nutritional strategies using a mechanistic computational model in prediabetes: Application to the J-DOIT1 study data.PloS one · 2023Article
- The Pediatric Obesity Encounter: Literature and Resources to Help with 4 Common Issues.Current nutrition reports · 2020Review
- The Many Faces of Obesity and Its Influence on Breast Cancer Risk.Frontiers in oncology · 2019Review
- Personalized Dietary Management of Overweight and Obesity Based on Measures of Insulin and Glucose.Annual review of nutrition · 2018Article
- ω-3 Fatty Acids, Impaired Fetal Growth, and Cardiovascular Risk: Nutrition as Precision Medicine.Advances in nutrition (Bethesda, Md.) · 2018Review
- Maintenance of Lost Weight and Long-Term Management of Obesity.The Medical clinics of North America · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo test for differential weight loss response to low-fat (LF) vs. low-carbohydrate (LC) diets by insulin resistance status with emphasis on overall quality of both diets.
methodsSixty-one adults, BMI 28-40 kg/m(2) , were randomized in a 2 × 2 design to LF or LC by insulin resistance status in this pilot study. Primary outcome was 6-month weight change. Participants were characterized as more insulin resistant (IR) or more insulin sensitive (IS) by median split of baseline insulin-area-under-the-curve from an oral glucose tolerance test. Intervention consisted of 14 one-hour class-based educational sessions.
resultsBaseline % carbohydrate:% fat:% protein was 44:38:18. At 6 months, the LF group reported 57:21:22 and the LC group reported 22:53:25 (IR and IS combined). Six-month weight loss (kg) was 7.4 ± 6.0 (LF-IR), 10.4 ± 7.8 (LF-IS), 9.6 ± 6.6 (LC-IR), and 8.6 ± 5.6 (LC-IS). No significant main effects were detected for weight loss by diet group or IR status; there was no significant diet × IR interaction. Significant differences in several secondary outcomes were observed.
conclusionsSubstantial weight loss was achieved overall, but a significant diet × IR status interaction was not observed. Opportunity to detect differential response may have been limited by the focus on high diet quality for both diet groups and sample size.
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