ArticlePediatric radiology2016
MR enterography-histology comparison in resected pediatric small bowel Crohn disease strictures: can imaging predict fibrosis?
Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Pooled it
- The prognostic role of magnetic resonance enterography at diagnosis in paediatric isolated ileocaecal Crohn's disease.Journal of pediatric gastroenterology and nutrition · 2026Article
- SAR Consensus Recommendations for Defining Small Bowel Crohn Disease Strictures at CT and MR Enterography.Radiology · 2025Review
- Computed Tomography and Magnetic Resonance Enterography: From Protocols to Diagnosis.Diagnostics (Basel, Switzerland) · 2024Review
- Quantitative MRI in children with Crohn's disease - where do we stand?Pediatric radiology · 2024Review
- Comprehensive review and update of stricturing Crohn's disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Potential applications of PET/MRI in non-oncologic conditions within the abdomen and pelvis.Abdominal radiology (New York) · 2023Review
- The Role of Magnetic Resonance Enterography in Crohn's Disease: A Review of Recent Literature.Diagnostics (Basel, Switzerland) · 2022Review
- Current and Emerging Approaches to the Diagnosis and Treatment of Crohn's Disease Strictures.Gastroenterology & hepatology · 2022Article
- Intestinal ultrasonography: a useful skill for efficient, non-invasive monitoring of patients with IBD using a clinic-based point-of-care approach.Frontline gastroenterology · 2022Article
- Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease.Inflammatory bowel diseases · 2021Article
- Flattening in the Anteroposterior Direction of the Terminal Ileum or Sigmoid Colon Lying Across the Psoas Muscle on Magnetic Resonance Enterography in Patients with Crohn's Disease.Korean journal of radiology · 2021Article
- Can Conventional and Diffusion-Weighted MR Enterography Biomarkers Differentiate Inflammatory from Fibrotic Strictures in Crohn's Disease?Medicina (Kaunas, Lithuania) · 2021Article
- Association Between Steroid-Sparing Therapy and the Risk of Perianal Fistulizing Complications Among Young Patients With Crohn Disease.JAMA network open · 2020Article
- IVIM with fractional perfusion as a novel biomarker for detecting and grading intestinal fibrosis in Crohn's disease.European radiology · 2019Article
- Characterization of Degree of Intestinal Fibrosis in Patients with Crohn Disease by Using Magnetization Transfer MR Imaging.Radiology · 2018Article
- Real-time elastography for the detection of fibrotic and inflammatory tissue in patients with stricturing Crohn's disease.Journal of ultrasound · 2017Article
- Ultrasound assessment of the bowel: inflammatory bowel disease and conditions beyond.Pediatric radiology · 2017Review
- Non-invasive evaluation of intestinal disorders: The role of elastographic techniques.World journal of gastroenterology · 2017Review
- Can Contrast-Enhanced Sonography Detect Bowel Wall Fibrosis in Mixed Inflammatory and Fibrotic Crohn Disease Lesions in an Animal Model?Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrohn disease is a chronic inflammatory condition that can lead to intestinal strictures. The presence of fibrosis within strictures alters optimal management but is not reliably detected by current imaging methods.
objectiveTo correlate the MRI features of surgically resected small-bowel strictures in pediatric Crohn disease with histological inflammation and fibrosis scoring. MATERIALS AND
methodsWe included children with Crohn disease who had symptomatic small-bowel strictures requiring surgical resection and had preoperative MR enterography (MRE) within 3 months of surgery (n = 20). Two blinded radiologists reviewed MRE examinations to document stricture-related findings. A pediatric pathologist scored stricture histological specimens for fibrosis (0-4) and inflammation (0-4). MRE findings were correlated with histological data using Spearman correlation (ρ) and exact logistic regression analysis.
resultsThere was significant positive correlation between histological bowel wall fibrosis and inflammation in resected strictures (ρ = 0.55; P = 0.01). Confluent transmural histological fibrosis was associated with pre-stricture upstream small-bowel dilatation >3 cm at univariate (odds ratio [OR] = 51.7; 95% confidence interval [CI]: 7.6- > 999.9; P = 0.0002) and multivariate (OR = 43.4; 95% CI: 6.1- > 999.9; P = 0.0006, adjusted for age) analysis. The degree of bowel wall T2-weighted signal intensity failed to correlate with histological bowel wall fibrosis or inflammation (P-values >0.05). There were significant negative correlations between histological fibrosis score and patient age at resection (ρ = -0.48, P = 0.03), and time from diagnosis to surgery (ρ = -0.73, P = 0.0002).
conclusionHistological fibrosis and inflammation co-exist in symptomatic pediatric Crohn disease small-bowel strictures and are positively correlated. Pre-stenotic upstream small-bowel dilatation greater than 3 cm is significantly associated with confluent transmural fibrosis.
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