Trial reportBMC musculoskeletal disorders2015
Extracorporeal shock wave therapy in the treatment of primary bone marrow edema syndrome of the knee: a prospective randomised controlled study.
Trial report in BMC musculoskeletal disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The use of extracorporeal shock wave therapy for the treatment of bone marrow oedema - a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Evaluation of treatment parameters for focused-extracorporeal shock wave therapy in knee osteoarthritis patients with bone marrow lesions: a pilot study.Journal of rehabilitation medicine · 2024Trial
- Beyond Cartilage Regeneration: Targeting the Subchondral Bone with Extracorporeal Shock Wave Therapy and Regenerative Medicine in Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2026Review
- [The value of physical therapy modalities for osteonecrosis and bone marrow edema : Current study situation and practical applicability in everyday clinical practice].Orthopadie (Heidelberg, Germany) · 2025Article
- A systematic review of the use of shockwave therapy for knee osteoarthritis.Journal of orthopaedics · 2024Review
- Increased nerve growth factor expression and osteoclast density are associated with subchondral bone marrow lesions in osteoarthritic knees.Osteoarthritis and cartilage open · 2024Article
- No dose response effect in shockwave therapy applied to bone conditions: a systematic review, meta-analysis and meta-regression.Journal of orthopaedics · 2024Review
- Experimental models of bone marrow lesions in ovine femoral condyles.Veterinary surgery : VS · 2023Article
- Multimodal conservative treatment of migrating bone marrow edema associated with early osteonecrosis of the hip.SAGE open medical case reports · 2022Article
- The Institute of Physical Medicine and Rehabilitation, Hospital das Clínicas University of São Paulo School of Medicine comprehensive rehabilitation program for elderly people with knee osteoarthritis.Frontiers in medicine · 2022Article
- Lower Limb Pain Attributed to Bone Marrow Edema Syndrome: A Commonly Ignored Pathology.Cureus · 2020Article
- High-energy focused extracorporeal shock wave therapy for bone marrow edema syndrome of the hip: A retrospective study.Medicine · 2020Observational
- Subchondroplasty in the Treatment of Bone Marrow Lesions of the Knee: Preliminary Experience on First 15 Patients.Joints · 2019Article
- Observational
- Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge.Blood advances · 2017Review
- BIPARTITE PATELLA IN 35-YEAR-OLD FITNESS INSTRUCTOR: A CASE REPORT.International journal of sports physical therapy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this prospective study was to evaluate the effectiveness of extracorporeal shock wave therapy (ESWT) in normalizing the symptoms and imaging features of primary bone marrow edema syndrome (BMES) of the knee.
methodsThis study compared the outcomes of ESWT (Group A) (n = 20) and intravenously applied prostacyclin and bisphosphonate (Group B) (n = 20) in the treatment of BMES of the knee in our department between 2011 and 2013. The Visual Analog Scale for pain (VAS, 100 mm), the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), the SF-36 scores and MRI scans as well as plain radiographs were obtained before and after therapy between two groups.
resultsCompared with Group B, we found greater improvement in VAS, the WOMAC Osteoarthritis Index and SF-36 score at 1, 3 and 6 months post-treatment in Group A (P < 0.05). Furthermore, MRI scans showed a higher incidence of distinct reduction and complete regression of bone marrow edema at 6 months in Group A (95 vs. 65 %; P = 0.018). The MRI at 1 year follow-up showed complete regression in all patients in Group A. However, two cases in Group B continued to normalize over the subsequent follow-up period.
conclusionsESWT can produce rapid pain relief and functional improvement. It may be an effective, reliable, and non-invasive technique for rapid treatment of BMES of the knee.
trial registrationResearch Registry UIN 528, September 03, 2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.