Evidence map›Paper›PMID 26637937›Full record

ArticleCell stem cell2015

More Frequent than Desired: Midgut Stem Cell Somatic Mutations.

Qi Li, Y Tony Ip

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Qi LiProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Y Tony IpProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: tony.ip@umassmed.edu.

Funding

University of Massachusetts Center for Clinical and Translational ScienceUL1TR000161 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2012 to 2015
$11.0M
Genetic analysis of damage-induced intestinal stem cell division in DrosophilaR01DK083450 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IP, Y. TONY · 2010 to 2024
$4.7M
Homeostatic signaling in the Drosophila intestineR01GM107457 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IP, Y. TONY · 2015 to 2018
$1.3M
NCATS NIH HHS UL1TR000161NIDDK NIH HHS DK83450NIDDK NIH HHS R01 DK083450NIGMS NIH HHS GM107457NIGMS NIH HHS R01 GM107457
6 · The paper itself

Abstract

The accumulation of somatic mutations in adult stem cells contributes to the decline of tissue functions and cancer initiation. In this issue of Cell Stem Cell, Siudeja et al. (2015) investigate the rate and mechanism of naturally occurring mutations in Drosophila midgut intestinal stem cells during aging and find high-frequency mutations arising from multiple mechanisms.

Indexed as

Adult Stem CellsAnimalsDrosophilaDrosophila melanogasterDrosophila ProteinsIntestinal MucosaMutationSignal TransductionStem CellsDrosophila Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.