Evidence map›Paper›PMID 26637657›Full record

ArticleCancer discovery2015

Overcoming Antigen Escape with CAR T-cell Therapy.

Hollie J Jackson, Renier J Brentjens

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer discovery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
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  8. Article
  9. Article
  10. Review
  11. Facts and Hopes: CAR T-Cell Therapy and Immune Contexture in Non-Hodgkin Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. "Digital twins elucidate critical role of TNPJ systems biology and applications · 2024
    Article
  18. Review
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Hollie J JacksonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Renier J BrentjensDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, New York. Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York. brentjer@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Sotillo and colleagues describe the molecular events associated with apparent loss of target antigen expression following CAR T-cell therapy. We propose that broader immune activation is required to prevent outgrowth of tumor antigen escape variants following targeted therapies.

Indexed as

Immunotherapy, AdoptiveAntigens, NeoplasmCell- and Tissue-Based TherapyHumansNeoplasmsReceptors, Antigen, T-CellT-LymphocytesAntigens, NeoplasmReceptors, Antigen, T-Cell

Identifiers

PMID26637657
PMCPMC5536095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.