ArticlePlant physiology2016
MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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132 citing papers in PubMed, 309 citations in OpenAlex.
- MdWRKY125 bridges cold condition and fruit flavor by activating the sucrose synthase geneaBIOTECH · 2026Article
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- Mechanism Underlying the Color Differences in Apples Based on Metabolomic and Transcriptomic Analyses.International journal of molecular sciences · 2026Article
- Molecular Mechanisms and Regulation of Anthocyanin Biosynthesis in Rosaceae Fruits: A Review.Food science & nutrition · 2026Review
- R2R3-MYB transcription factor MYB113 specifically regulates anthocyanin accumulation in Lycium ruthenicum.Plant cell reports · 2026Article
- Integrated Analysis of Metabolomics and Transcriptomics of the Differences in Flower Colors of Hybrid Cherry Blossoms.Plants (Basel, Switzerland) · 2026Article
- Overexpression of a Tonoplast Malate Transporter Gene Leads to Enhanced Anthocyanin Biosynthesis in Apple.Plant biotechnology journal · 2026Article
- Molecular insights into the regulation of flavonoid biosynthesis in fruits.Horticulture research · 2026Article
- Molecular orchestration of malate and citrate metabolism: regulatory networks governing organic acid dynamics and fruit quality attributes.Horticulture research · 2026Article
- Genome-wide identification of MYC transcription factors in Chrysanthemum morifolium and CmMYC25 promotes petal anthocyanin accumulation.Plant cell reports · 2026Article
- Comprehensive Analysis of Malate Accumulation in Peaches in Response to Cold Stress Based on Transcriptomics.Food science & nutrition · 2026Article
- Identification of candidate genes for malic acid content in tomato fruits and development of associated SNP markers.Frontiers in plant science · 2026Article
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- The vacuolar transporters MaMATE11 and MaMATE14 affect blue flower coloration in grape hyacinth (Horticulture research · 2026Article
- Genome-wide identification and expression analysis of the MYB transcription factor family inFrontiers in plant science · 2026Article
- Flavonoids: biological activities, nutritional and immunological aspects, therapeutic potential, food applications, and human health benefits-A comprehensive review.Frontiers in nutrition · 2026Review
- Integrated transcriptomic and metabolomic analyses delineate the biosynthetic pathways of functional components in maturingFood chemistry. Molecular sciences · 2025Article
- Integrated transcriptomic and metabolomic analysis reveals regulatory mechanisms underlying coloration differences in the pericarps of two Litchi cultivars.Food chemistry. Molecular sciences · 2025Article
- Malate accumulation and transcriptome patterns during fruit development in sweet Cherry (Prunus avium L.).BMC plant biology · 2025Article
- Transcriptomic and Metabolic Profiles of Apple Peels of Different Colors.Plants (Basel, Switzerland) · 2025Article
72 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants.
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