Evidence map›Paper›PMID 26637459›Full record

ArticleJournal of virology2016

Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells.

Andrea M Weiler, Arpita Das, Oluwasayo Akinyosoye, Sherry Cui, Shelby L O'Connor, Elizabeth A Scheef, Jason S Reed, Antonito T Panganiban, Jonah B Sacha, Eva G Rakasz and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Andrea M WeilerWisconsin National Primate Research Center, Madison, Wisconsin, USA.
Arpita DasDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Oluwasayo AkinyosoyeDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Sherry CuiBiomedical Sciences Training Program, Tulane University, New Orleans, Louisiana, USA.
Shelby L O'ConnorWisconsin National Primate Research Center, Madison, Wisconsin, USA Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Elizabeth A ScheefDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.
Jason S ReedDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Portland, Oregon, USA.
Antonito T PanganibanDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA Department of Microbiology and Immunology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
Jonah B SachaDivision of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Portland, Oregon, USA Vaccine & Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Sciences University, Portland, Oregon, USA.
Eva G RakaszWisconsin National Primate Research Center, Madison, Wisconsin, USA.
Thomas C FriedrichWisconsin National Primate Research Center, Madison, Wisconsin, USA Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Nicholas J ManessDivision of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA Department of Microbiology and Immunology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA nmaness@tulane.edu.
Tulane University · USOregon National Primate Research Center · USUniversity of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Defining the importance of CD8+ T Cell Breadth in SIV/HIV protective immunityR01AI084787 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FRIEDRICH, THOMAS C., O'CONNOR, DAVID H. · 2009 to 2013
$3.2M
SIV antisense epitopes as novel markers of latencyR21AI112447 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI MANESS, NICHOLAS JAMES · 2015 to 2016
$465k
NIAID NIH HHS AI 084787NIAID NIH HHS AI 112447NIAID NIH HHS R01 AI084787NIAID NIH HHS R21 AI112447NIAID NIH HHS U24 AI126683NIH HHS OD011104NIH HHS OD011106NIH HHS P51 OD011104NIH HHS P51 OD011106
6 · The paper itself

Abstract

Nef-specific CD8(+) T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef165-173IW9 epitope revealed highly restricted evolution. A common acute escape variant, T170I, unexpectedly and uniquely degraded Nef's major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.

Indexed as

Mutation, MissenseAnimalsCD8-Positive T-LymphocytesEpitopes, T-LymphocyteHigh-Throughput Nucleotide SequencingHistocompatibility Antigens Class IMacacaViral Regulatory and Accessory ProteinsEpitopes, T-LymphocyteHistocompatibility Antigens Class INEF protein, SIVViral Regulatory and Accessory Proteins

Identifiers

PMID26637459
PMCPMC4733980
OpenAlexW2395849993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.