ArticleCerebral cortex (New York, N.Y. : 1991)2016
Evidence for Competition for Target Innervation in the Medial Prefrontal Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Efficacy of Venlafaxine and Deep Brain Stimulation Against the Effects of Hippocampal Lesion with Ibotenic Acid in Animals Exposed to the Chronic Mild Stress Model of Depression.Current neuropharmacology · 2026Article
- Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia.Biological psychiatry · 2022Review
- Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function.Nature neuroscience · 2022Article
- Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.Neurobiology of stress · 2021Article
- Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study.Scientific reports · 2021Article
- Interneuron NMDA Receptor Ablation Induces Hippocampus-Prefrontal Cortex Functional Hypoconnectivity after Adolescence in a Mouse Model of Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction.Frontiers in behavioral neuroscience · 2020Article
- Article
- Adolescence as a neurobiological critical period for the development of higher-order cognition.Neuroscience and biobehavioral reviews · 2018Review
- Social Learning Requires Plasticity Enhanced by Fluoxetine Through Prefrontal Bdnf-TrkB Signaling to Limit Aggression Induced by Post-Weaning Social Isolation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Long-range orbitofrontal and amygdala axons show divergent patterns of maturation in the frontal cortex across adolescence.Developmental cognitive neuroscience · 2016Article
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Authors and funding
4 authors.
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Abstract
Inputs to sensory cortices are known to compete for target innervation through an activity-dependent mechanism during critical periods. To investigate whether this principle also applies to association cortices such as the medial prefrontal cortex (mPFC), we produced a bilateral lesion during early development to the ventral hippocampus (vHC), an input to the mPFC, and analyzed the intensity of the projection from another input, the basolateral amgydala (BLA). We found that axons from the BLA had a higher density of "en passant" boutons in the mPFC of lesioned animals. Furthermore, the density of neurons labeled with retrograde tracers was increased, and neurons projecting from the BLA to the mPFC showed increased expression of FosB. Since neonatal ventral hippocampal lesion has been used as an animal model of schizophrenia, we investigated its effects on behavior and found a negative correlation between the density of retrogradely labeled neurons in the BLA and the reduction of the startle response in the prepulse inhibition test. Our results not only indicate that the inputs from the BLA and the vHC compete for target innervation in the mPFC during postnatal development but also that subsequent abnormal rewiring might underlie the pathophysiology of neuropsychiatric disorders such as schizophrenia.
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