ArticleJournal of clinical microbiology2016
How Many Samples and How Many Culture Media To Diagnose a Prosthetic Joint Infection: a Clinical and Microbiological Prospective Multicenter Study.
Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Optimized use and performance of culture for periprosthetic joint infection diagnosis: a comprehensive literature review.Clinical microbiology reviews · 2025Pooled it
- Best microbiological practice recommendations for the diagnosis of peri-prosthetic joint infections: the CRIOGO bacteriology reference center network.Annals of clinical microbiology and antimicrobials · 2025Pooled it
- Contribution of sonication to the microbiology diagnosis of periprosthetic joint infection: Retrospective study of real-world data.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Optimization of sampling protocol, specimen types, and sampling sites in periprosthetic joint infections: a retrospective study.Journal of orthopaedic surgery and research · 2026Article
- Review
- The Usefulness of the Alpha-Defensin Lateral Flow Test in the Diagnosis of Prosthetic Infection: A Retrospective Cohort Study.Indian journal of orthopaedics · 2025Article
- Does a kidney stone culture make sense? The findings of microbiological cultures of kidney stones and correlation with stone composition, preoperative urine testing and postoperative SIRS.World journal of urology · 2025Article
- Prolonged incubation time unwarranted for acute periprosthetic joint infections.Journal of clinical microbiology · 2025Article
- A prospective evaluation of the inoculation of homogenised tissue and bone biopsies in blood culture bottles for the diagnosis of orthopaedic-device-related infections.Journal of bone and joint infection · 2025Article
- Future directions for early detection of fracture related infections.Journal of orthopaedics · 2024Article
- Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections.Clinical microbiology reviews · 2024Review
- Diagnostics in Late Periprosthetic Infections-Challenges and Solutions.Antibiotics (Basel, Switzerland) · 2024Review
- Optimized decision algorithm for the microbiological diagnosis of osteoarticular infections in adults using synovial fluid samples: a prospective study in two French hospitals including 423 samples of synovial fluid.Journal of bone and joint infection · 2024Article
- Microbiological Profile of Periprosthetic Knee Infections in a Brazilian Unified Health System Hospital Specialized in Highly Complex Orthopedic Surgeries.Revista brasileira de ortopedia · 2023Article
- The Role of Single Positive Cultures in Presumed Aseptic Total Hip and Knee Revision Surgery-A Systematic Review of the Literature.Diagnostics (Basel, Switzerland) · 2023Review
- Evaluation of two different semi-automated homogenization techniques in microbiological diagnosis of periprosthetic joint infection: disperser vs. bead milling method.BMC infectious diseases · 2022Article
- Reimplantation after Periprosthetic Joint Infection: The Role of Microbiology.Antibiotics (Basel, Switzerland) · 2022Article
- A postoperative brain abscess due to Propionibacterium acnes in an immunocompetent adult with incidental discovery.Annals of medicine and surgery (2012) · 2022Article
- Enhancing Diagnostics in Orthopedic Infections.Journal of clinical microbiology · 2022Review
- Microbiological Diagnosis of Osteoarticular Infections: Comparison between BacT/Alert Bottles and Schaedler Broth.Microbiology spectrum · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although numerous perioperative samples and culture media are required to diagnose prosthetic joint infection (PJI), their exact number and types have not yet been definitely determined with a high level of proof. We conducted a prospective multicenter study to determine the minimal number of samples and culture media required for accurate diagnosis of PJI. Over a 2-year period, consecutive patients with clinical signs suggesting PJI were included, with five perioperative samples per patient. The bacteriological and PJI diagnosis criteria were assessed using a random selection of two, three, or four samples and compared with those obtained using the recommended five samples (references guidelines). The results obtained with two or three culture media were then compared with those obtained with five culture media for both criteria. The times-to-positivity of the different culture media were calculated. PJI was confirmed in 215/264 suspected cases, with a bacteriological criterion in 192 (89%). The PJI was monomicrobial (85%) or polymicrobial (15%). Percentages of agreement of 98.1% and 99.7%, respectively, for the bacteriological criterion and confirmed PJI diagnosis were obtained when four perioperative samples were considered. The highest percentages of agreement were obtained with the association of three culture media, a blood culture bottle, a chocolate agar plate, and Schaedler broth, incubated for 5, 7, and 14 days, respectively. This new procedure leads to significant cost saving. Our prospective multicenter study showed that four samples seeded on three culture media are sufficient for diagnosing PJI.
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