Evidence map›Paper›PMID 26637321›Full record

Observational studyOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Gastrointestinal symptoms and association with medication use patterns, adherence, treatment satisfaction, quality of life, and resource use in osteoporosis: baseline results of the MUSIC-OS study.

A Modi, S Sen, J D Adachi, S Adami, B Cortet, A L Cooper, P Geusens, D Mellström, J Weaver, J P van den Bergh and 3 more

Open access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. A systematic review of factors affecting medication adherence among patients with osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Pooled it
  2. Article
  3. Article
  4. Treatment patterns in women with postmenopausal osteoporosis using abaloparatide: a real-world observational study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Observational
  5. Article
  6. Article
  7. Article
  8. Effect of Bisphosphonates on Fracture Outcomes Among Frail Older Adults.Journal of the American Geriatrics Society · 2019
    Article
  9. The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Observational
  10. Observational
  11. Article
  12. Association of gastrointestinal events with quality of life and treatment satisfaction in osteoporosis patients: results from the Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study (MUSIC OS).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 5 countries.

A ModiMerck and Co., Inc., Kenilworth, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.
S SenMerck and Co., Inc., Kenilworth, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.
J D AdachiDivision of Rheumatology, St. Joseph's Healthcare and McMaster University, Hamilton, ON, Canada.
S AdamiUniversity of Verona, Verona, Italy.
B CortetUniversity Hospital of Lille, Lille Cedex, France.
A L CooperBridge Medical Center, West Sussex, UK.
P GeusensMaastricht University Medical Center, Maastricht, Netherlands.
D MellströmUniversity of Gothenburg, Göteborg, Sweden.
J WeaverMerck and Co., Inc., Kenilworth, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA. jessica.weaver@merck.com.
J P van den BerghMaastricht University Medical Center, Maastricht, Netherlands.
A M NguyenMerck and Co., Inc., Kenilworth, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.
S SajjanMerck and Co., Inc., Kenilworth, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.
MUSIC-OS Study Group
Merck & Co., Inc., Rahway, NJ, USA (United States) · USMaastricht University · NLUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summaryThe Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study (MUSIC-OS) is a prospective, observational study of women with osteoporosis in Europe and Canada. At baseline, patients with gastrointestinal symptoms reported lower adherence to osteoporosis treatment, treatment satisfaction, and health-related quality of life, than those without gastrointestinal symptoms.

introductionThe aim of the study was to examine gastrointestinal (GI) symptoms and the association between GI symptoms and treatment adherence, treatment satisfaction, and health-related quality of life (HRQoL) among osteoporotic women in Europe and Canada.

methodsBaseline results are reported here for a prospective study which enrolled postmenopausal, osteoporotic women who were initiating (new users) or continuing (experienced users) osteoporosis treatment at study entry (baseline). A patient survey was administered at baseline and included the occurrence of GI symptoms during 6-month pre-enrolment, treatment adherence (adherence evaluation of osteoporosis (ADEOS), score 0-22), treatment satisfaction (Osteoporosis Treatment Satisfaction Questionnaire for Medications (OPSAT-Q), score 0-100) and HRQoL (EuroQol-5 dimension (EQ-5D) utility, score 0-1; OPAQ-SV, score 0-100). The association between GI symptoms and ADEOS (experienced users), OPSAT-Q (experienced users), and HRQoL (new and experienced users) was assessed by general linear models adjusted for patient characteristics.

resultsA total of 2959 patients (2275 experienced and 684 new users) were included. Overall, 68.1% of patients experienced GI symptoms in the past 6 months. Compared with patients without GI symptoms, patients with GI symptoms had lower mean baseline scores on most measures. The mean adjusted differences were ADEOS, -0.43; OPSAT-Q, -5.68; EQ-5D, -0.04 (new users) and -0.06 (experienced users), all P < 0.01. GI symptoms were also associated with lower OPAQ-SV domain scores: physical function, -4.17 (experienced users); emotional status, -4.28 (new users) and -5.68 (experienced users); back pain, -5.82 (new users) and -11.33 (experienced users), all P < 0.01.

conclusionsPatients with GI symptoms have lower treatment adherence and treatment satisfaction and worse HRQoL than patients without GI symptoms.

Indexed as

Drug MonitoringQuality of LifeAgedBone Density Conservation AgentsCanadaDiphosphonatesEuropeFemaleGastrointestinal DiseasesHealth ResourcesHumansMiddle AgedOsteoporosis, PostmenopausalPatient SatisfactionProspective StudiesPsychometricsBone Density Conservation AgentsDiphosphonatesBisphosphonatesGastrointestinalHealth-related quality of lifeOsteoporosisPostmenopausalTreatment satisfaction

Identifiers

PMID26637321
PMCPMC4767856
OpenAlexW2186049017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.