ArticleBiophysical journal2015
Fractal Characterization of Chromatin Decompaction in Live Cells.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Image analysis tools for improved characterization of nuclear chromatin patterns by confocal fluorescence microscopy.European biophysics journal : EBJ · 2026Article
- Convolutional neural network-based regression analysis to predict subnuclear chromatin organization from two-dimensional optical scattering signals.Journal of biomedical optics · 2024Article
- Nucleosome spacing controls chromatin spatial structure and accessibility.Biophysical journal · 2024Article
- Multiscale optical phase fluctuations link disorder strength and fractal dimension of cell structure.Biophysical journal · 2023Article
- Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids.Science advances · 2021Article
- Assessment of internal refractive index profile of stochastically inhomogeneous nuclear models via analysis of two-dimensional optical scattering patterns.Journal of biomedical optics · 2021Article
- LED array reflectance microscopy for scattering-based multi-contrast imaging.Optics letters · 2020Article
- Inverse scattering for reflection intensity phase microscopy.Biomedical optics express · 2020Article
- Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring.Scientific reports · 2019Article
- Detection of Malignancy in Ocular Surface Lesions by Inverse Spectroscopic Optical Coherence Tomography and Two-Photon Autofluorescence.Translational vision science & technology · 2019Article
- Histone variants on the move: substrates for chromatin dynamics.Nature reviews. Molecular cell biology · 2017Review
- Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography.Physics in medicine and biology · 2016Article
- Optical Detection of Early Damage in Retinal Ganglion Cells in a Mouse Model of Partial Optic Nerve Crush Injury.Investigative ophthalmology & visual science · 2016Article
- Dynamic Nucleosome Movement Provides Structural Information of Topological Chromatin Domains in Living Human Cells.PLoS computational biology · 2016Article
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Authors and funding
5 authors.
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Abstract
Chromatin organization has a fundamental impact on the whole spectrum of genomic functions. Quantitative characterization of the chromatin structure, particularly at submicron length scales where chromatin fractal globules are formed, is critical to understanding this structure-function relationship. Such analysis is currently challenging due to the diffraction-limited resolution of conventional light microscopy. We herein present an optical approach termed inverse spectroscopic optical coherence tomography to characterize the mass density fractality of chromatin, and we apply the technique to observe chromatin decompaction in live cells. The technique makes it possible for the first time, to our knowledge, to sense intracellular morphology with length-scale sensitivity from ∼30 to 450 nm, thus primarily probing the higher-order chromatin structure, without resolving the actual structures. We used chromatin decompaction due to inhibition of histone deacytelases and measured the subsequent changes in the fractal dimension of the intracellular structure. The results were confirmed by transmission electron microscopy and confocal fluorescence microscopy.
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