Evidence map›Paper›PMID 26636903›Full record

ArticleCell cycle (Georgetown, Tex.)2016

Metabolic coupling in urothelial bladder cancer compartments and its correlation to tumor aggressiveness.

Julieta Afonso, Lúcio L Santos, António Morais, Teresina Amaro, Adhemar Longatto-Filho, Fátima Baltazar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Julieta Afonsoa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
Lúcio L Santosc Department of Surgical Oncology , Portuguese Institute of Oncology (IPO) , Porto , Portugal.
António Moraise Department of Urology , Portuguese Institute of Oncology (IPO) , Porto , Portugal.
Teresina Amarof Experimental Pathology and Therapeutics Research Center, Portuguese Institute of Oncology (IPO) , Porto , Portugal.
Adhemar Longatto-Filhoa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
Fátima Baltazara Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
University of Minho · PTFernando Pessoa University · PTHospital São Paulo · BRInstituto Português de Oncologia Francisco Gentil · PTIPO Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocarboxylate transporters (MCTs) are vital for intracellular pH homeostasis by extruding lactate from highly glycolytic cells. These molecules are key players of the metabolic reprogramming of cancer cells, and evidence indicates a potential contribution in urothelial bladder cancer (UBC) aggressiveness and chemoresistance. However, the specific role of MCTs in the metabolic compartmentalization within bladder tumors, namely their preponderance on the tumor stroma, remains to be elucidated. Thus, we evaluated the immunoexpression of MCTs in the different compartments of UBC tissue samples (n = 111), assessing the correlations among them and with the clinical and prognostic parameters. A significant decrease in positivity for MCT1 and MCT4 occurred from normoxic toward hypoxic regions. Significant associations were found between the expression of MCT4 in hypoxic tumor cells and in the tumor stroma. MCT1 staining in normoxic tumor areas, and MCT4 staining in hypoxic regions, in the tumor stroma and in the blood vessels were significantly associated with UBC aggressiveness. MCT4 concomitant positivity in hypoxic tumor cells and in the tumor stroma, as well as positivity in each of these regions concomitant with MCT1 positivity in normoxic tumor cells, was significantly associated with an unfavourable clinicopathological profile, and predicted lower overall survival rates among patients receiving platinum-based chemotherapy. Our results point to the existence of a multi-compartment metabolic model in UBC, providing evidence of a metabolic coupling between catabolic stromal and cancer cells' compartments, and the anabolic cancer cells. It is urgent to further explore the involvement of this metabolic coupling in UBC progression and chemoresistance.

Indexed as

AdultAgedAged, 80 and overCarbonic Anhydrase IXCarcinomaDisease-Free SurvivalDisease ProgressionFemaleHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersMuscle ProteinsCarbonic Anhydrase IXMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersMuscle ProteinsSLC16A4 protein, humanSymporterschemoresistancemetabolic compartmentsmonocarboxylate transporterstumor stromaurothelial bladder cancer

Identifiers

PMID26636903
PMCPMC4943695
OpenAlexW2291869867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.