Trial reportPloS one2015
Early Hepatic Dysfunction Is Associated with a Worse Outcome in Patients Presenting with Acute Respiratory Distress Syndrome: A Post-Hoc Analysis of the ACURASYS and PROSEVA Studies.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Development and validation of a clinical risk model to predict the hospital mortality in ventilated patients with acute respiratory distress syndrome: a population-based study.BMC pulmonary medicine · 2022Trial
- Trial
- Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial.Critical care (London, England) · 2017Trial
- Human umbilical cord-derived mesenchymal stem cell exosomes ameliorate hepatocyte ferroptosis and sepsis-associated liver injury by restoring iron homeostasis in hepatocytes.Journal of nanobiotechnology · 2026Article
- Total bilirubin as a marker for hemolysis and outcome in patients with severe ARDS treated with veno-venous ECMO.BMC anesthesiology · 2025Article
- Impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis.Scientific reports · 2025Article
- Clinical Use of Nomogram Based on Machine Learning for Diagnosis Prediction of Acute Respiratory Distress Syndrome in Patients With Acute Pancreatitis.Mediators of inflammation · 2025Article
- An interpretable machine learning model for predicting mortality risk in adult ICU patients with acute respiratory distress syndrome.Frontiers in medicine · 2025Article
- Outcomes and time trends of acute respiratory distress syndrome patients with and without liver cirrhosis: an observational cohort.Annals of intensive care · 2023Article
- Risk Factors for the In-Hospital Mortality in Pyogenic Vertebral Osteomyelitis: A Cross-Sectional Study on 9753 Patients.Journal of clinical medicine · 2023Article
- The Gut Microbiota Contributes to Systemic Responses and Liver Injury in Gut-Derived Sepsis.Microorganisms · 2023Article
- Predictors associated with mortality of veno-venous extracorporeal membrane oxygenation therapy.Journal of thoracic disease · 2023Article
- Total bilirubin is associated with all-cause mortality in patients with acute respiratory distress syndrome: a retrospective study.Annals of translational medicine · 2022Article
- Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients.Critical care (London, England) · 2022Review
- Commentary: Serum total bilirubin with hospital survival in adults during extracorporeal membrane oxygenation.Frontiers in medicine · 2022Article
- Synapomorphic features of hepatic and pulmonary vasculatures include comparable purinergic signaling responses in host defense and modulation of inflammation.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Extracorporeal multiorgan support including COThe International journal of artificial organs · 2021Article
- Gadolinium Chloride Inhibits the Production of Liver Interleukin-27 and Mitigates Liver Injury in the CLP Mouse Model.Mediators of inflammation · 2021Article
- Liver-lung interactions in acute respiratory distress syndrome.Intensive care medicine experimental · 2020Article
- Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis.EMBO molecular medicine · 2020Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBilirubin is well-recognized marker of hepatic dysfunction in intensive care unit (ICU) patients. Multiple organ failure often complicates acute respiratory distress syndrome (ARDS) evolution and is associated with high mortality. The effect of early hepatic dysfunction on ARDS mortality has been poorly investigated. We evaluated the incidence and the prognostic significance of increased serum bilirubin levels in the initial phase of ARDS.
methodsThe data of 805 patients with ARDS were retrospectively analysed. This population was extracted from two recent multicenter, prospective and randomised trials. Patients presenting with ARDS with a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen < 150 mmHg measured with a PEEP ≥ 5 cm of water were included. The total serum bilirubin was measured at inclusion and at days 2, 4, 7 and 14. The primary objective was to analyse the bilirubin at inclusion according to the 90-day mortality rate.
resultsThe 90-day mortality rate was 33.8% (n = 272). The non-survivors were older, had higher Sepsis-related Organ Failure Assessment (SOFA) score and were more likely to have a medical diagnosis on admission than the survivors. At inclusion, the SOFA score without the liver score (10.3±2.9 vs. 9.0±3.0, p<0.0001) and the serum bilirubin levels (36.1±57.0 vs. 20.5±31.5 μmol/L, p<0.0001) were significantly higher in the non-survivors than in the survivors. Age, the hepatic SOFA score, the coagulation SOFA score, the arterial pH level, and the plateau pressure were independently associated with 90-day mortality in patients with ARDS.
conclusionBilirubin used as a surrogate marker of hepatic dysfunction and measured early in the course of ARDS was associated with the 90-day mortality rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.