Evidence map›Paper›PMID 26636247›Full record

ArticleHypertension in pregnancy2015

Racial Disparities in Comorbidities, Complications, and Maternal and Fetal Outcomes in Women With Preeclampsia/eclampsia.

Sajid Shahul, Avery Tung, Mohammed Minhaj, Junaid Nizamuddin, Julia Wenger, Eitezaz Mahmood, Ariel Mueller, Shahzad Shaefi, Barbara Scavone, Robb D Kociol and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Hypertension in pregnancy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06220721 (Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia), which is not on this map. Cited by 79 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 4 pooled it
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06220721 narecruitingnot on this mapstarted 2024, after this paper: background citation

Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia

TypeinterventionalSponsorMedical College of WisconsinRan2024 to 2029Enrolled618ConditionsHypertension, Pregnancy-InducedArmsNifedipine ER
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 158 citations in OpenAlex.

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  14. [Headaches following childbirth-severe ARDS in postpartum eclampsia].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Sajid Shahula Department of Anesthesia and Critical Care , University of Chicago , Chicago , IL , USA .
Avery Tunga Department of Anesthesia and Critical Care , University of Chicago , Chicago , IL , USA .
Mohammed Minhaja Department of Anesthesia and Critical Care , University of Chicago , Chicago , IL , USA .
Junaid Nizamuddina Department of Anesthesia and Critical Care , University of Chicago , Chicago , IL , USA .
Julia Wengerc Division of Nephrology , Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA .
Eitezaz Mahmoodb Department of Anesthesiology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA .
Ariel Muellerb Department of Anesthesiology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA .
Shahzad Shaefib Department of Anesthesiology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA .
Barbara Scavonea Department of Anesthesia and Critical Care , University of Chicago , Chicago , IL , USA .
Robb D Kociold Department of Medicine , CardioVascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA .
Daniel Talmorb Department of Anesthesiology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA .
Sarosh Ranae Division of Maternal Fetal Medicine/Department of Obstetrics and Gynecology , University of Chicago , Chicago , IL , USA.
University of Chicago · USHarvard University · USBeth Israel Deaconess Medical Center · US

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Angiogenic factors, abnormal placentation and adverse pregnancy outcomesK08HD068398 · NICHD · UNIVERSITY OF CHICAGO · PI RANA, SAROSH · 2012 to 2014
$390k
NCATS NIH HHS UL1 TR000430NICHD NIH HHS K08 HD068398
6 · The paper itself

Abstract

objectiveThe mechanisms leading to worse outcomes in African-American (AA) women with preeclampsia/eclampsia remain unclear. Our objective was to identify racial differences in maternal comorbidities, peripartum characteristics, and maternal and fetal outcomes. METHODS/

resultsWhen compared to white women with preeclampsia/eclampsia, AA women had an increased unadjusted risk of inpatient maternal mortality (OR 3.70, 95% CI: 2.19-6.24). After adjustment for covariates, in-hospital mortality for AA women remained higher than that for white women (OR 2.85, 95% CI: 1.38-5.53), while the adjusted risk of death among Hispanic women did not differ from that for white women. We also found an increased risk of intrauterine fetal death (IUFD) among AA women. When compared to white women with preeclampsia, AA women had an increased unadjusted odds of IUFD (OR 2.78, 95% CI: 2.49-3.11), which remained significant after adjustment for covariates (adjusted OR 2.45, 95% CI: 2.14-2.82). In contrast, IUFD among Hispanic women did not differ from that for white women after adjusting for covariates. CONCLUSIONS AND RELEVANCE: Our data suggest that African-American women are more likely to have risk factors for preeclampsia and more likely to suffer an adverse outcome during peripartum care. Future research should examine whether controlling co-morbidities and other risk factors will help to alleviate racial disparities in outcomes in this cohort of women.

Indexed as

epidemiologyHypertensionmortality

Identifiers

PMID26636247
PMCPMC4782921
OpenAlexW2194872486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.