ArticleJournal of nature and science2015
Interaction of expanding abdominal aortic aneurysm with surrounding tissue: Retrospective CT image studies.
Article in Journal of nature and science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Region-specific gene expression and sex inform about disease susceptibility in the aorta.Nature cardiovascular research · 2025Article
- Quantification of the heterogeneous effect of static and dynamic perivascular structures on patient-specific local aortic wall mechanics using inverse finite element modeling and DENSE MRI.Journal of biomechanics · 2022Article
- Patient-Specific Inverse Modeling of In Vivo Cardiovascular Mechanics with Medical Image-Derived Kinematics as Input Data: Concepts, Methods, and Applications.Applied sciences (Basel, Switzerland) · 2022Article
- Perivascular mechanical environment: A narrative review of the role of externally applied mechanical force in the pathogenesis of atherosclerosis.Frontiers in cardiovascular medicine · 2022Review
- Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management.Computer methods and programs in biomedicine · 2021Article
- Patient-Specific Prediction of Abdominal Aortic Aneurysm Expansion Using Bayesian Calibration.IEEE journal of biomedical and health informatics · 2019Article
- Prediction of Abdominal Aortic Aneurysm Growth Using Dynamical Gaussian Process Implicit Surface.IEEE transactions on bio-medical engineering · 2019Article
- Detecting Regional Stiffness Changes in Aortic Aneurysmal Geometries Using Pressure-Normalized Strain.Ultrasound in medicine & biology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesAbdominal aortic aneurysms (AAA) that rupture have a high mortality rate. Rupture occurs when local mechanical stress exceeds the local mechanical strength of an AAA, so stress profiles such as those from finite element analysis (FEA) are useful. The role and effect of surrounding tissues, like the vertebral column, which have not been extensively studied, are examined in this paper.
methodsLongitudinal CT scans from ten patients with AAAs were studied to see the effect of surrounding tissues on AAAs. Segmentation was performed to distinguish the AAA from other tissues and we studied how these surrounding tissues affected the shape and curvature of the AAA. Previously established methods by Veldenz et al. were used to split the AAA into 8 sections and examine the specific effects of surrounding tissues on these sections [1]. Three-dimensional models were created to better examine these effects over time. Registration was done in order to compare AAAs longitudinally.
resultsThe vertebral column and osteophytes were observed to have been affecting the shape and the curvature of the AAA. Interaction with the spine caused focal flattening in certain areas of the AAA. In 16 of the 41 CT scans, the right posterior dorsal section (section 5), had the highest radius of curvature, which was by far the section that had the maximum radius for a specified CT scan. Evolution of the growing AAA showed increased flattening in this section when comparing the last CT scan to the first scan.
conclusionSurrounding tissues have a clear influence on the geometry of an AAA, which may in turn affect the stress profile of AAA. Incorporating these structures in FEA and G&R models will provide a better estimate of stress. CLINICAL RELEVANCE: Currently, size is the only variable considered when deciding whether to undergo elective surgery to repair AAA since it is an easy enough measure for clinicians to utilize. However, this may not be the best indicator of rupture risk because small aneurysms also contribute to a high mortality rate. AAA's wall stress is a superior indicator and may be better predicted with the inclusion of these surrounding tissues, which then could be used by clinicians in their decision-making process on whether to operate on an AAA.
Identifiers
26636132PMC4666317W2116247530What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.