ArticleJournal of dentistry (Shiraz, Iran)2015
P63 and Ki-67 Expression in Dentigerous Cyst and Ameloblastomas.
Article in Journal of dentistry (Shiraz, Iran), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- The Expression of Selected Wnt Pathway Members (FZD6, AXIN2 and β-Catenin) in Canine Oral Squamous Cell Carcinoma and Acanthomatous Ameloblastoma.Animals : an open access journal from MDPI · 2021Article
- p63 Expression and its Relation to Epithelial Cells Proliferation in Dentigerous Cyst, Odontogenic Keratocyst, and Ameloblastoma.Pathology oncology research : POR · 2020Article
- Desmoplastic Ameloblastoma Arising in a Dentigerous Cyst - A Case Report and Discussion.Journal of clinical and diagnostic research : JCDR · 2016Article
- Proliferative and anti-apoptotic indices of unicystic ameloblastoma, odontogenic keratocyst, dentigerous cyst and radicular cyst.Journal of oral and maxillofacial pathology : JOMFPArticle
- Immunohistochemical expression of osteonectin, matrix metalloproteinases-9 and Ki-67 in ameloblastoma.Journal of oral and maxillofacial pathology : JOMFPArticle
- P63 and Ki-67 expression in radicular cyst.Journal of oral biology and craniofacial researchArticle
- MCM3 and Ki67 proliferation markers in odontogenic cysts and ameloblastoma.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
statement of the problemP63 gene is a member of TP53 and its homologous gene family. Its expression was observed in some odontogenic lesions, more expression in aggressive lesions. PURPOSE: This study aimed to investigate the possible diagnostic impact of P63 protein on dentigerous cysts and various types of ameloblastoma. Its expression with Ki-67 proliferation marker was also compared. MATERIALS AND
methodThis cross-sectional retrospective study was enrolled on 25 cases of dentigerous cyst including 21 unicystic ameloblastomas and 17 conventional ameloblastomas. The expression of P63 and Ki-67 was assessed by immunohistochemical (IHC) examinations. Data were analyzed by employing Mann-Whitney and correlation coefficient tests.
resultsP63 expression was significantly higher in ameloblastoma than unicystic ameloblastoma and dentigerous cysts. There was no significant difference between unicystic ameloblastoma and dentigerous cyst in P63 expression. A 90% cut-off point was obtained for basal layer which gave 88% sensitivity and 78% specificity to distinguish more invasive lesions from others. There was not any correlation between P63 and Ki-67 immunostaining in the three study groups.
conclusionMore aggressiveness and more invasiveness of odontogenic lesions depicted higher rate and also more intensive expression of P63. Moreover, the expression of P63 protein had not any correlation with Ki-67 protein in dentigerous cysts and ameloblastomas.
Indexed as
Identifiers
26636120PMC4664029W2175443094What OpenQuestion holds
Registered trials
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