ReviewFrontiers in bioengineering and biotechnology2015
Synthetic Protein Scaffolds Based on Peptide Motifs and Cognate Adaptor Domains for Improving Metabolic Productivity.
Review in Frontiers in bioengineering and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Protein design drives synthetic biology research of plant natural products.Biodesign research · 2025Review
- Construction of cell factory through combinatorial metabolic engineering for efficient production of itaconic acid.Microbial cell factories · 2022Article
- The optimal docking strength for reversibly tethered kinases.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The challenges and prospects of Escherichia coli as an organic acid production host under acid stress.Applied microbiology and biotechnology · 2021Review
- Synthetic Scaffold Systems for Increasing the Efficiency of Metabolic Pathways in Microorganisms.Biology · 2021Review
- Analysis of Engineered Tobacco Mosaic Virus and Potato Virus X Nanoparticles as Carriers for Biocatalysts.Frontiers in plant science · 2021Article
- Refining Metabolic Mass Transfer for Efficient Biosynthesis of Plant Natural Products in Yeast.Frontiers in bioengineering and biotechnology · 2021Review
- Enzyme Assembly for Compartmentalized Metabolic Flux Control.Metabolites · 2020Review
- Microbial Cell Factory for Efficiently Synthesizing Plant Natural Products via Optimizing the Location and Adaptation of Pathway on Genome Scale.Frontiers in bioengineering and biotechnology · 2020Review
- Orthogonal Synthetic Zippers as Protein Scaffolds.ACS omega · 2018Article
- Membrane-Located Expression of Thioesterase FromFrontiers in microbiology · 2018Article
- Cellular factories for coenzyme QMicrobial cell factories · 2017Review
- Engineering the Bacterial Microcompartment Domain for Molecular Scaffolding Applications.Frontiers in microbiology · 2017Article
- A roadmap for biocatalysis - functional and spatial orchestration of enzyme cascades.Microbial biotechnology · 2016Review
- Characterizing Aciniform Silk Repetitive Domain Backbone Dynamics and Hydrodynamic Modularity.International journal of molecular sciences · 2016Article
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Authors and funding
2 authors.
Funding
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Abstract
The efficiency of many cellular processes relies on the defined interaction among different proteins within the same metabolic or signaling pathway. Consequently, a spatial colocalization of functionally interacting proteins has frequently emerged during evolution. This concept has been adapted within the synthetic biology community for the purpose of creating artificial scaffolds. A recent advancement of this concept is the use of peptide motifs and their cognate adaptor domains. SH2, SH3, GBD, and PDZ domains have been used most often in research studies to date. The approach has been successfully applied to the synthesis of a variety of target molecules including catechin, D-glucaric acid, H2, hydrochinone, resveratrol, butyrate, gamma-aminobutyric acid, and mevalonate. Increased production levels of up to 77-fold have been observed compared to non-scaffolded systems. A recent extension of this concept is the creation of a covalent linkage between peptide motifs and adaptor domains, which leads to a more stable association of the scaffolded systems and thus bears the potential to further enhance metabolic productivity.
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