ReviewFrontiers in pediatrics2015
Neonatal Seizures: Impact on Neurodevelopmental Outcomes.
Review in Frontiers in pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Treating the symptom or treating the disease in neonatal seizures: a systematic review of the literature.Italian journal of pediatrics · 2021Pooled it
- Neonatal predictors of neurodevelopment: the interplay between APGAR score and neonatal microbiome.Irish journal of medical science · 2026Review
- Multi-organ involvement in preterm neonatal encephalopathy.Early human development · 2025Article
- Treatment of neonatal seizures: from guidelines to precision therapy.Molecular and cellular pediatrics · 2025Article
- Cenobamate suppresses seizures without inducing cell death in neonatal rats.Epilepsy & behavior : E&B · 2024Article
- Pharmacokinetics and safety of brivaracetam in neonates with repeated electroencephalographic seizures: A multicenter, open-label, single-arm study.Epilepsia open · 2024Article
- Case report: Acute severe hyponatremia-induced seizures in a newborn: a community-acquired case and literature review.Frontiers in pharmacology · 2024Article
- Predictors of poor neurodevelopmental outcomes in neonates with clinically observed seizures: A prospective observational study in a tertiary care hospital of Bangladesh.Epilepsy & behavior reports · 2024Article
- Efficacy of Levetiracetam as Add-On Therapy in the Treatment of Seizures in Neonates.Neonatology · 2024Article
- Questions and Controversies in Neonatal Seizures.Children (Basel, Switzerland) · 2023Review
- Treating Hyperexcitability in Human Cerebral Organoids Resulting from Oxygen-Glucose Deprivation.Cells · 2023Article
- Continuous electroencephalography in the intensive care unit: A critical review and position statement from an Australian and New Zealand perspective.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023Article
- A Commentary on Electrographic Seizure Management and Clinical Outcomes in Critically Ill Children.Children (Basel, Switzerland) · 2023Article
- Validation of central nervous system-induced seizures and other neurological variables in the Swedish Neonatal Quality Register.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Effectiveness of vagus nerve stimulation therapy in refractory hypoxic-ischemic encephalopathy-induced epilepsy.Therapeutic advances in neurological disorders · 2022Article
- Brain CT Scan, Sonography and EEG Findings in Neonates with Seizure.Iranian journal of child neurology · 2022Article
- Targeting ischemia-induced KCC2 hypofunction rescues refractory neonatal seizures and mitigates epileptogenesis in a mouse model.Science signaling · 2021Article
- Multiscale Entropy Analysis of Heart Rate Variability in Neonatal Patients with and without Seizures.Bioengineering (Basel, Switzerland) · 2021Article
- Novel Concepts for the Role of Chloride Cotransporters in Refractory Seizures.Aging and disease · 2021Review
- Neonatal Seizures and Purinergic Signalling.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neonatal period is the most vulnerable time for the occurrence of seizures, and neonatal seizures often pose a clinical challenge both for their acute management and frequency of associated long-term co-morbidities. Etiologies of neonatal seizures are known to play a primary role in the anti-epileptic drug responsiveness and the long-term sequelae. Recent studies have suggested that burden of acute recurrent seizures in neonates may also impact chronic outcomes independent of the etiology. However, not many studies, either clinical or pre-clinical, have addressed the long-term outcomes of neonatal seizures in an etiology-specific manner. In this review, we briefly review the available clinical and pre-clinical research for long-term outcomes following neonatal seizures. As the most frequent cause of acquired neonatal seizures, we focus on the studies evaluating long-term effects of HIE-seizures with the goal to evaluate (1) what parameters evaluated during acute stages of neonatal seizures can reliably be used to predict long-term outcomes? and (2) what available clinical and pre-clinical data are available help determine importance of etiology vs. seizure burdens in long-term sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.