ArticleIranian journal of pediatrics2015
Primary Antibiotic Resistance to Helicobacter pylori Strains Isolated From Children in Northern Iran: A Single Center Study.
Article in Iranian journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The prevalence of clarithromycin-resistantPeerJ · 2023Pooled it
- Global Profile of Drug Resistance Related toHealth science reports · 2025Review
- Current Worldwide Trends in PediatricChildren (Basel, Switzerland) · 2023Review
- The high sensitivity and specificity of rapid urease test in diagnosis ofIranian journal of microbiology · 2022Article
- Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran.BMC research notes · 2021Article
- Article
- Review
- Helicobacter pylori Infection in Pediatric Patients: Update on Diagnosis and Eradication Strategies.Paediatric drugs · 2018Review
- Eradication ofMiddle East journal of digestive diseases · 2018Review
- Prevalence and Associated Symptoms ofInterdisciplinary perspectives on infectious diseases · 2018Article
- Resistance ofWorld journal of gastroenterology · 2017Article
- Furazolidone, an Underutilized Drug for H. pylori Eradication: Lessons from Iran.Digestive diseases and sciences · 2017Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInitial resistance to antibiotics is the main reason for the failure of Helicobacter pylori (H. pylori) eradication in children.
objectivesAs we commonly face high antibiotic resistance rates in children, we aimed to determine the susceptibility of H. pylori to common antibiotics. PATIENTS AND
methodsIn this cross-sectional in vitro study, 169 children younger than 14 years with clinical diagnosis of peptic ulcer underwent upper gastrointestinal endoscopy. Biopsy specimens from stomach and duodenum were cultured. In isolated colonies, tests of catalase, urease, and oxidase as well as gram staining were performed. After confirming the colonies as H. pylori, the antibiogram was obtained using disk diffusion method.
resultsCulture for H. pylori was positive in 12.3% of the specimens, urease test in 21.3%, serological test in 18.9% and stool antigen test was positive in 21.9%. We could show high specificity but moderate sensitivity of both histological and H. pylori stool antigen tests to detect H. pylori. The overall susceptibility to metronidazole was 42.9%, amoxicillin 95.2%, clarithromycin 85.7%, furazolidone 61.9%, azithromycin 81.0%, and tetracycline 76.2% with the highest resistance to metronidazole and the lowest to clarithromycin.
conclusionsIn our region, there is high resistance of H. pylori to some antibiotics including metronidazole and furazolidone among affected children. To reduce the prevalence of this antibiotic resistance, more controlled use of antibiotics should be considered in children.
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