Evidence map›Paper›PMID 26635922›Full record

ReviewWorld journal of cardiology2015

Therapeutic modification of arterial stiffness: An update and comprehensive review.

Ching-Fen Wu, Pang-Yen Liu, Tsung-Jui Wu, Yuan Hung, Shih-Ping Yang, Gen-Min Lin

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  10. Vascular Aging: Assessment and Intervention.Clinical interventions in aging · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Ching-Fen WuChing-Fen Wu, Department of Internal Medicine, Mennonite Christian Hospital, Hualien 97144, Taiwan.
Pang-Yen LiuChing-Fen Wu, Department of Internal Medicine, Mennonite Christian Hospital, Hualien 97144, Taiwan.
Tsung-Jui WuChing-Fen Wu, Department of Internal Medicine, Mennonite Christian Hospital, Hualien 97144, Taiwan.
Yuan HungChing-Fen Wu, Department of Internal Medicine, Mennonite Christian Hospital, Hualien 97144, Taiwan.
Shih-Ping YangChing-Fen Wu, Department of Internal Medicine, Mennonite Christian Hospital, Hualien 97144, Taiwan.
Gen-Min LinChing-Fen Wu, Department of Internal Medicine, Mennonite Christian Hospital, Hualien 97144, Taiwan.
National Defense Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with long-term worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovascular risk. Additionally to life style modifications, long-term ω-3 fatty acids (fish oil) supplementation in diet may improve arterial stiffness in the population with hypertension or metabolic syndrome. Pharmacological treatment such as renin-angiotensin-aldosterone system antagonists, metformin, and 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors were useful in individuals with hypertension and diabetes. In obese population with obstructive sleep apnea, weight reduction, aerobic exercise, and continuous positive airway pressure treatment may also improve arterial stiffness. In the populations with chronic inflammatory disease such as rheumatoid arthritis, a use of antibodies against tumor necrosis factor-alpha could work effectively. Other therapeutic options such as renal sympathetic nerve denervation for patients with resistant hypertension are investigated in many ongoing clinical trials. Therefore our comprehensive review provides knowledge in detail regarding many aspects of pathogenesis, measurement, and management of arterial stiffness in several populations, which would be helpful for physicians to make clinical decision.

Indexed as

Arterial stiffnessCardio-ankle vascular indexPulse-wave velocityRenin-angiotensin-aldosterone system antagonist

Identifiers

PMID26635922
PMCPMC4660469
OpenAlexW2210524848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.