Evidence map›Paper›PMID 26635907›Full record

ArticleImmunology, endocrine & metabolic agents in medicinal chemistry2009

Targeting the fatty acid transport proteins (FATP) to understand the mechanisms linking fatty acid transport to metabolism.

Paul N Black, Angel Sandoval, Elsa Arias-Barrau, Concetta C DiRusso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, endocrine & metabolic agents in medicinal chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Lipid homeostasis in diabetic kidney disease.International journal of biological sciences · 2024
    Pooled it
  2. Review
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  4. Article
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  6. Article
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  8. Article
  9. Review
  10. Article
  11. Review
  12. The role of candidate transport proteins in β-cell long-chain fatty acid uptake: Where are we now?Diabetic medicine : a journal of the British Diabetic Association · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Endothelial Lipid Metabolism.Cold Spring Harbor perspectives in medicine · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Paul N BlackDepartment of Biochemistry, University of Nebraska, Lincoln, NE 68583, USA.
Angel SandovalDepartment of Biochemistry, University of Nebraska, Lincoln, NE 68583, USA.
Elsa Arias-BarrauDepartment of Biochemistry, University of Nebraska, Lincoln, NE 68583, USA.
Concetta C DiRussoDepartment of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583, USA ; Department of Biochemistry, University of Nebraska, Lincoln, NE 68583, USA.
University of Nebraska–Lincoln · US

Funding

High throughput screens for fatty acid uptake inhibitorsR01DK071076 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI BLACK, PAUL N., DIRUSSO, CONCETTA C. · 2006 to 2013
$2.4M
MOLECULAR ANALYSIS OF FATTY ACID TRANSPORT IN EUKARYOTESR01GM056840 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BLACK, PAUL N., DIRUSSO, CONCETTA C. · 1998 to 2010
$2.3M
NIDDK NIH HHS R01 DK071076NIGMS NIH HHS R01 GM056840
6 · The paper itself

Abstract

One principal process driving fatty acid transport is vectorial acylation, where fatty acids traverse the membrane concomitant with activation to CoA thioesters. Current evidence is consistent with the proposal that specific fatty acid transport (FATP) isoforms alone or in concert with specific long chain acyl CoA synthetase (Acsl) isoforms function to drive this energy-dependent process. Understanding the details of vectorial acylation is of particular importance as disturbances in lipid metabolism many times leads to elevated levels of circulating free fatty acids, which in turn increases fatty acid internalization and ectopic accumulation of triglycerides. This is associated with changes in fatty acid oxidation rates, accumulation of reactive oxygen species, the synthesis of ceramide and ER stress. The correlation between chronically elevated plasma free fatty acids and triglycerides with the development of obesity, insulin resistance and cardiovascular disease has led to the hypothesis that decreases in pancreatic insulin production, cardiac failure, arrhythmias, and hypertrophy are due to aberrant accumulation of lipids in these tissues. To this end, a detailed understanding of how fatty acids traverse the plasma membrane, become activated and trafficked into downstream metabolic pools and the precise roles provided by the different FATP and Acsl isoforms are especially important questions. We review our current understanding of vectorial acylation and the contributions by specific FATP and Acsl isoforms and the identification of small molecule inhibitors from high throughput screens that inhibit this process and thus provide new insights into the underlying mechanistic basis of this process.

Identifiers

PMID26635907
PMCPMC4665979
OpenAlexW1984232893

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.