Evidence map›Paper›PMID 26635887›Full record

ArticlePersonalized medicine2015

Clinician Perspectives on Using Pharmacogenomics in Clinical Practice.

Kim M Unertl, Habiba Jaffa, Julie R Field, Lisa Price, Josh F Peterson

Erratum issuedAbstract read
In one paragraph

Article in Personalized medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effect of genetics clinical decision support tools on health-care providers' decision making: a mixed-methods systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Advancing Pharmacogenomics from Single-Gene to Preemptive Testing.Annual review of genomics and human genetics · 2022
    Review
  18. Pharmacists' Knowledge, and Insights in Implementing Pharmacogenomics in Saudi Arabia.International journal of environmental research and public health · 2022
    Article
  19. Article
  20. Pharmacogenetic Testing Knowledge and Attitudes among Pediatric Psychiatrists and Pediatricians in Alberta, Canada.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kim M UnertlDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN.
Habiba JaffaThe University of Manchester, Manchester, UK, M13 9PL.
Julie R FieldInstitute of Clinical and Translational Research, Vanderbilt University School of Medicine, Nashville, TN.
Lisa PriceInstitute of Clinical and Translational Research, Vanderbilt University School of Medicine, Nashville, TN.
Josh F PetersonDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN ; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
Pharmacogenomics of Anti-platlet Intervention-2 (PAPI-2) StudyU01HL105198 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2010 to 2014
$13.6M
Integrated, Individualized, Intelligent Prescribing (I3P)U01HG007253 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEVY, MIA A., PETERSON, JOSEPH F. · 2014 to 2018
$4.6M
Vanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0M
Rational Integration of Genomic Healthcare Testing (RIGHT)U01HL122904 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRAVES, JOHN A., PETERSON, JOSEPH F. · 2013 to 2016
$1.9M
PHARMACOGENOMIC RESOURCE FOR ENHANCED DECISIONS IN CLOPIDOGREL TREATMENT (PREDICTU47CI000824 · CI · VANDERBILT UNIVERSITY · PI LAPOSATA, MICHAEL · 2011 to 2012
$998k
NCATS NIH HHS UL1 TR000445NCPDCID CDC HHS U47 CI000824NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG007253NHLBI NIH HHS U01 HL105198NHLBI NIH HHS U01 HL122904NHLBI NIH HHS U19 HL065962
6 · The paper itself

Abstract

aimTo describe the knowledge and attitudes of clinicians participating in a large pharmacogenomics implementation program. MATERIALS &

methodsSemi-structured interviews with 15 physicians and nurse practitioners were conducted.

resultsThree categories of themes were identified: preparation and knowledge, pharmacogenomics usage in practice, and future management of genomic variants. Providers expressed an inability to keep up with the rapid pace of evidence generation and indicated strong support for clinical decision support to assist with genotype-tailored therapies. Concerns raised by clinicians included effectively communicating results, long-term responsibility for actionable results and hand-offs with providers outside the implementation program.

conclusionsClinicians identified their own knowledge deficits, workflow integration, and longitudinal responsibility as challenges to successful usage of pharmacogenomics in clinical practice.

Indexed as

attitudespersonalized medicinepharmacogenomicsqualitative researchtranslational research

Identifiers

PMID26635887
PMCPMC4664195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.