Evidence map›Paper›PMID 26635773›Full record

ReviewFrontiers in microbiology2015

Elucidating Host-Pathogen Interactions Based on Post-Translational Modifications Using Proteomics Approaches.

Vaishnavi Ravikumar, Carsten Jers, Ivan Mijakovic

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. MS-BasedACS infectious diseases · 2020
    Article
  6. Review
  7. Sweet and SourFrontiers in microbiology · 2019
    Article
  8. Genome Wide Phosphoproteome Analysis ofFrontiers in microbiology · 2019
    Article
  9. Article
  10. Frontiers in cellular and infection microbiology · 2018
    Article
  11. Article
  12. Article
  13. Article
  14. Frontiers in cellular and infection microbiology · 2017
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vaishnavi RavikumarSystems and Synthetic Biology Division, Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg, Sweden.
Carsten JersDepartment of Systems Biology, Technical University of Denmark , Lyngby, Denmark.
Ivan MijakovicSystems and Synthetic Biology Division, Department of Biology and Biological Engineering, Chalmers University of Technology , Gothenburg, Sweden ; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Hørsholm, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbes with the capability to survive in the host tissue and efficiently subvert its innate immune responses can cause various health hazards. There is an inherent need to understand microbial infection patterns and mechanisms in order to develop efficient therapeutics. Microbial pathogens display host specificity through a complex network of molecular interactions that aid their survival and propagation. Co-infection states further lead to complications by increasing the microbial burden and risk factors. Quantitative proteomics based approaches and post-translational modification analysis can be efficiently applied to gain an insight into the molecular mechanisms involved. The measurement of the proteome and post-translationally modified proteome dynamics using mass spectrometry, results in a wide array of information, such as significant changes in protein expression, protein abundance, the modification status, the site occupancy level, interactors, functional significance of key players, potential drug targets, etc. This mini review discusses the potential of proteomics to investigate the involvement of post-translational modifications in bacterial pathogenesis and host-pathogen interactions.

Indexed as

bacteriaco-culturespathogenesispost-translational modificationsproteomics

Identifiers

PMID26635773
PMCPMC4653285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.