Evidence map›Paper›PMID 26635728›Full record

ReviewFrontiers in endocrinology2015

Contribution of GnIH Research to the Progress of Reproductive Neuroendocrinology.

Kazuyoshi Tsutsui, Takayoshi Ubuka, You Lee Son, George E Bentley, Lance J Kriegsfeld

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 70 citations in OpenAlex.

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  17. RFamide-related peptide-3 (RFRP-3) suppresses sexual maturation in a eusocial mammal.Proceedings of the National Academy of Sciences of the United States of America · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Kazuyoshi TsutsuiLaboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University , Tokyo , Japan.
Takayoshi UbukaLaboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University , Tokyo , Japan ; Brain Research Institute Monash Sunway of the Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia , Petaling Jaya , Malaysia.
You Lee SonLaboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University , Tokyo , Japan.
George E BentleyDepartment of Integrative Biology, Helen Wills Neuroscience Institute, University of California at Berkeley , Berkeley, CA , USA.
Lance J KriegsfeldDepartment of Psychology, Helen Wills Neuroscience Institute, University of California at Berkeley , Berkeley, CA , USA.
Waseda University · JPUniversity of California, Berkeley · US

Funding

The role of kisspeptin and RFRP-3 in the neuroendocrine control of female reproductionR01HD050470 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRIEGSFELD, LANCE J · 2007 to 2022
$5.0M
NICHD NIH HHS R01 HD050470
6 · The paper itself

Abstract

Since the discovery of gonadotropin-releasing hormone (GnRH) in mammals at the beginning of the 1970s, it was generally accepted that GnRH is the only hypothalamic neuropeptide regulating gonadotropin release in mammals and other vertebrates. In 2000, however, gonadotropin-inhibitory hormone (GnIH), a novel hypothalamic neuropeptide that actively inhibits gonadotropin release, was discovered in quail. Numerous studies over the past decade and a half have demonstrated that GnIH serves as a key player regulating reproduction across vertebrates, acting on the brain and pituitary to modulate reproductive physiology and behavior. In the latter case, recent evidence indicates that GnIH can regulate reproductive behavior through changes in neurosteroid, such as neuroestrogen, biosynthesis in the brain. This review summarizes the discovery of GnIH, and the contributions to GnIH research focused on its mode of action, regulation of biosynthesis, and how these findings advance our understanding of reproductive neuroendocrinology.

Indexed as

gonadotropin-inhibitory hormonegonadotropin-releasing hormonegonadotropinsmelatoninreproductionreproductive behaviorsocial environmentstress

Identifiers

PMID26635728
PMCPMC4655308
OpenAlexW2185272311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.