ArticleFrontiers in neurology2015
A Systematic Review and Meta-Analysis of the Functional MRI Investigation of Motor Neuron Disease.
Article in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Magnetic Resonance Neuroimaging in Amyotrophic Lateral Sclerosis: A Comprehensive Umbrella Review of 18 Studies.Brain sciences · 2025Review
- Model-Based and Model-Free Analyses of the Neural Correlates of Tongue Movements.Frontiers in neuroscience · 2020Article
- Monitoring Value of Multimodal Magnetic Resonance Imaging in Disease Progression of Amyotrophic Lateral Sclerosis: A Prospective Observational Study.Chinese medical journal · 2018Observational
- Frontotemporal Dementia in Amyotrophic Lateral Sclerosis: From Rarity to Reality?Neurology international · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess the use of functional magnetic resonance imaging (fMRI) in motor neuron disease (MND), a systematic review and voxelwise meta-analysis of studies comparing brain activity in patients with MND and in healthy controls was conducted to identify common findings across studies.
methodsA search for related papers published in English and Chinese was performed in Ovid Medline, Pubmed, and Embase database. Voxelwise meta-analysis was performed using signed differential mapping.
resultsThe findings from 55 fMRI studies on MND were tabulated, and some common findings were discussed in further details.
conclusionThese findings are preliminary, sometimes even contradictory, and do not allow a complete understanding of the functional alterations in MND. However, we documented reliable findings that MND is not confined to the motor system, but is a multisystem disorder involving extra-motor cortex areas, causing cognitive dysfunction and deficits in socioemotional and sensory processing pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.