Evidence map›Paper›PMID 26635720›Full record

ArticleFrontiers in neurology2015

Brain Network Activation as a Novel Biomarker for the Return-to-Play Pathway Following Sport-Related Brain Injury.

Adam W Kiefer, Kim Barber Foss, Amit Reches, Brooke Gadd, Michael Gordon, Ken Rushford, Ilan Laufer, Michal Weiss, Gregory D Myer

Abstract readCase Reports
In one paragraph

Article in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam W KieferDivision of Sports Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, OH , USA ; Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH , USA ; Center for Cognition Action and Perception, Department of Psychology, University of Cincinnati , Cincinnati, OH , USA.
Kim Barber FossDivision of Sports Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, OH , USA.
Amit RechesElMindA Ltd , Herzliya , Israel.
Brooke GaddDivision of Sports Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, OH , USA.
Michael GordonSt. Xavier High School , Cincinnati, OH , USA.
Ken RushfordSt. Xavier High School , Cincinnati, OH , USA.
Ilan LauferElMindA Ltd , Herzliya , Israel.
Michal WeissElMindA Ltd , Herzliya , Israel.
Gregory D MyerDivision of Sports Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, OH , USA ; Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, OH , USA ; Department of Orthopaedic Surgery, University of Cincinnati , Cincinnati, OH , USA ; The Micheli Center for Sports Injury Prevention , Waltham, MA , USA ; Sports Health and Performance Institute, The Ohio State University , Columbus, OH , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children and adolescent athletes are at a higher risk for concussion than adults, and also experience longer recovery times and increased associated symptoms. It has also recently been demonstrated that multiple, seemingly mild concussions may result in exacerbated and prolonged neurological deficits. Objective assessments and return-to-play criteria are needed to reduce risk and morbidity associated with concussive events in these populations. Recent research has pushed to study the use of electroencephalography as an objective measure of brain injury. In the present case study, we present a novel approach that examines event-related potentials via a brain network activation (BNA) analysis as a biomarker of concussion and recovery. Specifically, changes in BNA scores, as indexed through this approach, offer a potential indicator of neurological health as the BNA assessment qualitatively and quantitatively indexes the network dynamics associated with brain injury. Objective tools, such as these support accurate and efficient assessment of brain injury and may offer a useful step in categorizing the temporal and spatial changes in brain activity following concussive blows, as well as the functional connectivity of brain networks, associated with concussion.

Indexed as

brain network activationconcussionEEGhockeyreturn to play

Identifiers

PMID26635720
PMCPMC4653293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.