ReviewFrontiers in physiology2015
Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome.
Review in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Urolithin A: a multi-target therapeutic candidate derived from the gut microbiota for obesity and metabolic dysfunction.Frontiers in endocrinology · 2026Review
- The melatonin-microbiome axis: a new frontier in gut health for the immunomodulatory, antioxidant and anti-inflammatory properties.Inflammopharmacology · 2026Review
- Postprandial Inflammation in Obesity: Dietary Determinants, Adipose Tissue Dysfunction and the Gut Microbiome.Biomolecules · 2025Review
- Inulin supplementation exhibits increased muscle mass via gut-muscle axis in children with obesity: double evidence from clinical and in vitro studies.Scientific reports · 2024Article
- Article
- The Impact of Dietary Fiber as a Prebiotic on Inflammation in Children with Obesity.Foods (Basel, Switzerland) · 2022Article
- Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2021Article
- Pb Toxicity on Gut Physiology and Microbiota.Frontiers in physiology · 2021Review
- Combined effects of HIV and obesity on the gastrointestinal microbiome of young men who have sex with men.HIV medicine · 2020Article
- NOD2 Deficiency Promotes Intestinal CD4+ T Lymphocyte Imbalance, Metainflammation, and Aggravates Type 2 Diabetes in Murine Model.Frontiers in immunology · 2020Article
- The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin GDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Colonic Microbiota Encroachment Correlates With Dysglycemia in Humans.Cellular and molecular gastroenterology and hepatology · 2017Article
- Macrophage functions in lean and obese adipose tissue.Metabolism: clinical and experimental · 2017Review
- [Beneficial effect of periodontal therapy on insulin resistance and lipid metabolism in obese rats with periodontitis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites.Scientific reports · 2017Article
- Impact of Westernized Diet on Gut Microbiota in Children on Leyte Island.Frontiers in microbiology · 2017Article
- White blood cell inflammatory markers are associated with depressive symptoms in a longitudinal study of urban adults.Translational psychiatry · 2016Article
- Distribution and Characteristics of Colonic Diverticula in a United States Screening Population.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2016Article
- UPDATING THE CONCEPT OF METABOLICALLY HEALTHY OBESITY.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intimate interplay between immune system, metabolism, and gut microbiota plays an important role in controlling metabolic homeostasis and possible obesity development. Obesity involves impairment of immune response affecting both innate and adaptive immunity. The main factors involved in the relationship of obesity with inflammation have not been completely elucidated. On the other hand, gut microbiota, via innate immune receptors, has emerged as one of the key factors regulating events triggering acute inflammation associated with obesity and metabolic syndrome. Inflammatory disorders lead to several signaling transduction pathways activation, inflammatory cytokine, chemokine production and cell migration, which in turn cause metabolic dysfunction. Inflamed adipose tissue, with increased macrophages infiltration, is associated with impaired preadipocyte development and differentiation to mature adipose cells, leading to ectopic lipid accumulation and insulin resistance. This review focuses on the relationship between obesity and inflammation, which is essential to understand the pathological mechanisms governing metabolic syndrome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.