ArticleFrontiers in pharmacology2015
Antimicrobial, Anthelmintic Activities and Characterisation of Functional Phenolic Acids of Achyranthes aspera Linn.: A Medicinal Plant Used for the Treatment of Wounds and Ringworm in East Africa.
Article in Frontiers in pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Herbal Medicine for the Management of Wounds: A Systematic Review of Clinical Studies.Infectious disorders drug targets · 2025Pooled it
- Phytochemical Composition and Antibacterial Activity of Medicinal Plants Against Bacterial Pathogens Isolated From Livestock Wound Infections.MicrobiologyOpen · 2026Article
- Host phylogeny and microbiome composition predict gut nematode community composition within a diverse assemblage of African herbivores.Biology letters · 2026Article
- Development, Characterization, and Evaluation of Topical Antibacterial Formulations From Achyranthes aspera.BioMed research international · 2026Article
- African Medicinal Plants in Cutaneous Wound Repair: A Comprehensive Analysis of the Role of Phytochemicals.International wound journal · 2025Review
- Article
- Analysis ofBiochemistry and biophysics reports · 2024Article
- Article
- Phytochemical Content, Antibacterial Activity, and Antioxidant, Anti-Inflammatory, and Cytotoxic Effects of Traditional Medicinal Plants against Respiratory Tract Bacterial Pathogens.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Herbal Arsenal against Skin Ailments: A Review Supported by In Silico Molecular Docking Studies.Molecules (Basel, Switzerland) · 2022Review
- Phenolic degradation by catechol dioxygenases is associated with pathogenic fungi with a necrotrophic lifestyle in the Ceratocystidaceae.G3 (Bethesda, Md.) · 2022Article
- Preliminary Phytochemical Composition andEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution?Frontiers in pharmacology · 2021Review
- Investigation of Wound Healing and Anti-Inflammatory Activities of Solvent Fractions of 80% Methanol Leaf Extract ofJournal of inflammation research · 2021Article
- Comprehensive Characterization of Secondary Metabolites fromInternational journal of molecular sciences · 2020Article
- Qualitative Phytochemical Fingerprint and Network Pharmacology Investigation ofMolecules (Basel, Switzerland) · 2020Article
- Chemical Constituents ofMolecules (Basel, Switzerland) · 2019Article
- Antibacterial Activity of Two Flavans from the Stem Bark ofAdvances in pharmacological sciences · 2018Article
- Achyranthes aspera Attenuates epilepsy in experimental animals: possible involvement of GABAergic mechanism.Metabolic brain disease · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Achyranthes aspera Linn. (Amaranthaceae) commonly known as Prickly Chaff flower (English) is traditionally used for treating a number of ailments. Different parts of the plant are used in treating wounds and ringworm in East Africa and elsewhere for a number of ailments. In this study, leaf extracts of A. aspera collected from two different geographical locations (Ciaat, Eritrea and Ukulinga, South Africa) were evaluated for antibacterial, antifungal, anthelmintic activities and the plant characterized for functional phenolic acids as well as protein binding capacity. The pathogens used in the tests were, two Gram-negative (Escherichia coli and Klebsiella pneumoniae), two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), a filamentus yeast-like fungus (Candida albicans) and a free-living nematode (Caenorhabditis elegans). The water and acetone extracts of the samples collected from Ciaat exhibited good antibacterial, antifungal and anthelmintic activity (MIC < 1 mg/ml) except the water extract against E. coli which showed moderate activity. In contrast, the extracts collected from Ukulinga exhibited moderate to weak activities except for the acetone (aq.) extracts which had good activity against some of the tested organisms. UHPLC-MS/MS revealed variation in the levels of some functional phenolic compounds, with rutin, chlorogenic acid and genistein not being detected in the extracts from Ukulinga. The variation was also observed in the protein binding capacity, which could offer a predictive wound healing model. All extracts from plant samples collected at Ciaat expressed significant dominant potency compared to similar extracts from Ukulinga.
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