ArticleFrontiers in human neuroscience2015
Functional Connectivity of EEG Signals Under Laser Stimulation in Migraine.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Pain-Related Fear Modulates Attentional Bias for Threat Processing in Chronic Pain: An ERP Study.Journal of pain research · 2026Article
- EEG Changes in Migraine-Can EEG Help to Monitor Attack Susceptibility?Brain sciences · 2024Review
- The applied principles of EEG analysis methods in neuroscience and clinical neurology.Military Medical Research · 2023Review
- Habituation to Pain in Patients with Chronic Pain: Clinical Implications and Future Directions.Journal of clinical medicine · 2023Review
- Application of EEG in migraine.Frontiers in human neuroscience · 2023Review
- Article
- Migraine Visual Aura and Cortical Spreading Depression-Linking Mathematical Models to Empirical Evidence.Vision (Basel, Switzerland) · 2021Article
- Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference.Brain sciences · 2021Review
- Dynamic Causal Modelling of the Reduced Habituation to Painful Stimuli in Migraine: An EEG Study.Brain sciences · 2020Article
- Pearls and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability-part I.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Cortical pain processing in migraine.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study.The journal of headache and pain · 2019Article
- Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain.NeuroImage. Clinical · 2019Article
- Sensory Modulation Disorder (SMD) and Pain: A New Perspective.Frontiers in integrative neuroscience · 2019Article
- Visual input drives increased occipital responsiveness and harmonized oscillations in multiple cortical areas in migraineurs.NeuroImage. Clinical · 2019Article
- Pain Perception and Migraine.Frontiers in neurology · 2018Review
- Brain networking analysis in migraine with and without aura.The journal of headache and pain · 2017Article
- Resting-state EEG power and coherence vary between migraine phases.The journal of headache and pain · 2016Article
- Multi-frequency analysis of brain connectivity networks in migraineurs: a magnetoencephalography study.The journal of headache and pain · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In previous studies, migraine patients showed abnormalities in pain-related evoked responses, as reduced habituation to repetitive stimulation. In this study, we aimed to apply a novel analysis of EEG bands synchronization and directed dynamical influences under painful stimuli in migraine patients compared to non-migraine healthy volunteers. Thirty-one migraine without aura outpatients (MIGR) were evaluated and compared to 19 controls (CONT). The right hand was stimulated by means of 30 consecutive CO2 laser stimuli. EEG signal was examined by means of Morlet wavelet, synchronization entropy (SE), and Granger causality (GC), and the statistically validated results were mapped on the corresponding scalp locations. The vertex complex of averaged laser-evoked responses (LEPs) showed reduced habituation compared to CONT. In the prestimulus phase, enhanced SE in the 0, 5-30 Hz range was present in MIGR and CONT between the bilateral temporal-parietal and the frontal regions around the midline. Migraine patients showed an anticipation of EEG changes preceding the painful stimulation compared to CONT. In the poststimulus phase, the same cortical areas were more connected in MIGR vs CONT. In both groups of patients and CONT, the habituation index was negatively correlated with the GC scores. A different pattern of cortical activation after painful stimulation was present in migraine. The increase in cortical connections during repetitive painful stimulation may subtend the phenomenon of LEPs reduced habituation. Brain network analysis may give an aid in understanding subtle changes of pain processing under laser stimuli in migraine patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.