ArticleFrontiers in human neuroscience2015
Dissociable Roles of Dorsolateral Prefrontal Cortex and Frontal Eye Fields During Saccadic Eye Movements.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Eye movements and ocular biomarkers in mild traumatic brain injury: from oculomotor pathophysiology to diagnosis and prognosis.Journal of neurology · 2026Review
- Rapid modulation of choice behavior by ultrasound on the human frontal eye fields.Nature communications · 2026Article
- Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer's disease therapy.Frontiers in pharmacology · 2025Review
- Exploring oculomotor functions in a pilot study with healthy controls: Insights from eye-tracking and fMRI.PloS one · 2024Article
- Neuromodulation on the ground and in the clouds: a mini review of transcranial direct current stimulation for altering performance in interactive driving and flight simulators.Frontiers in psychology · 2024Review
- Time-on-task effects on human pupillary and saccadic metrics after theta burst transcranial magnetic stimulation over the frontal eye field.IBRO neuroscience reports · 2023Article
- Investigation of changes in the activity and function of dry eye-associated brain regions using the amplitude of low-frequency fluctuations method.Bioscience reports · 2022Article
- A guide for concurrent TMS-fMRI to investigate functional brain networks.Frontiers in human neuroscience · 2022Article
- Investigating the role of human frontal eye field in the pupil light reflex modulation by saccade planning and working memory.Frontiers in human neuroscience · 2022Article
- Eye Movements in Mild Traumatic Brain Injury: Ocular Biomarkers.Journal of eye movement research · 2022Article
- Eye-Tracking Training Improves Inhibitory Control in Children with Attention-Deficit/Hyperactivity Disorder.Brain sciences · 2021Article
- Computerized Eye-Tracking Training Improves the Saccadic Eye Movements of Children with Attention-Deficit/Hyperactivity Disorder.Brain sciences · 2020Article
- Dorsolateral prefrontal cortex hyperactivity during inhibitory control in children with ADHD in the antisaccade task.Brain imaging and behavior · 2020Article
- Altered spontaneous brain activity patterns in diabetic patients with vitreous hemorrhage using amplitude of low‑frequency fluctuation: A resting‑state fMRI study.Molecular medicine reports · 2020Article
- Causal Evidence for the Role of Neuronal Oscillations in Top-Down and Bottom-Up Attention.Journal of cognitive neuroscience · 2019Article
- The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS-EEG study.Human brain mapping · 2019Article
- Hippocampal-targeted Theta-burst Stimulation Enhances Associative Memory Formation.Journal of cognitive neuroscience · 2018Article
- Altered brain network centrality in patients with adult comitant exotropia strabismus: A resting-state fMRI study.The Journal of international medical research · 2018Article
- Assessing the Functional Role of Frontal Eye Fields in Voluntary and Reflexive Saccades Using Continuous Theta Burst Stimulation.Frontiers in neuroscience · 2018Article
- Prenatal maternal cortisol concentrations predict neurodevelopment in middle childhood.Psychoneuroendocrinology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
The dorsolateral prefrontal cortex (DLPFC) and the frontal eye fields (FEF) have both been implicated in the executive control of saccades, yet possible dissociable roles of each region have not been established. Specifically, both establishing a "task set" as well as suppressing an inappropriate response have been linked to DLPFC and FEF activity, with behavioral outcome measures of these mechanisms mainly being the percentage of pro-saccade errors made on anti-saccade trials. We used continuous theta-burst stimulation (cTBS) to disrupt FEF or DLPFC function in humans during an anti-saccade task to assess the causal role of these regions in these executive control processes, and in programming saccades towards (pro-saccade) or away (anti-saccade) from visual targets. After right FEF cTBS, as compared to control cTBS to the right primary somatosensory cortex (rS1), anti-saccade amplitude of the first saccade decreased and the number of anti-saccades to acquire final position increased; however direction errors to the visual target were not different. In contrast, after left DLPFC cTBS, as compared to left S1 cTBS, subjects displayed greater direction errors for contralateral anti-saccades; however, there were no impairments on the number of saccades or the saccade amplitude. These results are consistent with the notion that DLPFC is necessary for executive control of saccades, whereas FEF is necessary for visuo-motor aspects of anti-saccade programming.
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