ReviewFrontiers in systems neuroscience2015
Prospects for Optogenetic Augmentation of Brain Function.
Review in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex.Advanced healthcare materials · 2026Article
- An optrode array for spatiotemporally-precise large-scale optogenetic stimulation of deep cortical layers in non-human primates.Communications biology · 2024Article
- Therapeutic Neuromodulation toward a Critical State May Serve as a General Treatment Strategy.Biomedicines · 2022Article
- Chronically implantable LED arrays for behavioral optogenetics in primates.Nature methods · 2021Article
- Dynamic real-time subtraction of stray-light and background for multiphoton imaging.Biomedical optics express · 2021Article
- Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles.Neurosurgery · 2019Review
- Engineered Axonal Tracts as "Living Electrodes" for Synaptic-Based Modulation of Neural Circuitry.Advanced functional materials · 2018Article
- Theoretical Principles of Multiscale Spatiotemporal Control of Neuronal Networks: A Complex Systems Perspective.Frontiers in computational neuroscience · 2018Article
- The brain is required for normal muscle and nerve patterning during early Xenopus development.Nature communications · 2017Article
- And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation.Frontiers in neuroscience · 2017Review
- Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine.Frontiers in bioengineering and biotechnology · 2017Review
- The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects.CNS drugs · 2016Review
- Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation.Frontiers in neuroscience · 2016Review
- Review of Brain-Machine Interfaces Used in Neural Prosthetics with New Perspective on Somatosensory Feedback through Method of Signal Breakdown.Scientifica · 2016Review
- Metabolomic Analysis in Brain Research: Opportunities and Challenges.Frontiers in physiology · 2016Article
- Progress in Neuroengineering for brain repair: New challenges and open issues.Brain and neuroscience advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to optically control neural activity opens up possibilities for the restoration of normal function following neurological disorders. The temporal precision, spatial resolution, and neuronal specificity that optogenetics offers is unequalled by other available methods, so will it be suitable for not only restoring but also extending brain function? As the first demonstrations of optically "implanted" novel memories emerge, we examine the suitability of optogenetics as a technique for extending neural function. While optogenetics is an effective tool for altering neural activity, the largest impediment for optogenetics in neural augmentation is our systems level understanding of brain function. Furthermore, a number of clinical limitations currently remain as substantial hurdles for the applications proposed. While neurotechnologies for treating brain disorders and interfacing with prosthetics have advanced rapidly in the past few years, partially addressing some of these critical problems, optogenetics is not yet suitable for use in humans. Instead we conclude that for the immediate future, optogenetics is the neurological equivalent of the 3D printer: its flexibility providing an ideal tool for testing and prototyping solutions for treating brain disorders and augmenting brain function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.