ArticleMediators of inflammation2015
Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis.
Article in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Innate Immune Response to Helminth Infections.Advances in experimental medicine and biology · 2025Review
- Association of IL-9 Cytokines with Hepatic Injury inBiomolecules · 2024Article
- Macrophage-mediated mechanisms of lung injury in the sensitization reaction toFrontiers in immunology · 2024Article
- The regulatory role of differential microRNA expressions on cellular inflammatory factors IL-6 and IL-10 in Echinococcus granulosus-induced anaphylaxis.Immunity, inflammation and disease · 2023Article
- LncRNA Regulation Mechanism in Hepatic Alveolar Echinococcosis with Nanosecond Pulse.Acta parasitologica · 2023Article
- Impact of Albendazole on Cytokine and Chemokine Response Profiles inBioMed research international · 2021Article
- The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis.BMC infectious diseases · 2020Article
- Recent advances on innate immune pathways related to host-parasite cross-talk in cystic and alveolar echinococcosis.Parasites & vectors · 2020Review
- Comprehensive Analysis of Non-coding RNA Profiles of Exosome-Like Vesicles From the Protoscoleces and Hydatid Cyst Fluid ofFrontiers in cellular and infection microbiology · 2020Article
- Echinococcus multilocularis inoculation induces NK cell functional decrease through high expression of NKG2A in C57BL/6 mice.BMC infectious diseases · 2019Article
- Subcutaneous Inoculation of Echinococcus multilocularis Induces Delayed Regeneration after Partial Hepatectomy.Scientific reports · 2019Article
- The potential role of toll-like receptor 4 Asp299Gly polymorphism and its association with recurrent cystic echinococcosis in postoperative patients.Parasitology research · 2018Article
- Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis.Scientific reports · 2018Article
- Expression of toll-like receptor 2, 4 and related cytokines in intraperitoneally inoculated Balb/C mice withInternational journal of clinical and experimental pathology · 2017Article
- Up-regulated TLR2 and TLR4 expressions in liver and spleen during acute murine T. gondii infection.Parasitology research · 2016Article
- Dysregulation of Ovine Toll-Like Receptors 2 and 4 Expression by Hydatid Cyst-Derived Antigens.Iranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have demonstrated the important role of Toll-like receptors in various parasitic infections. This study aims to explore expression of Toll-like receptors (TLRs) and related cytokines in patients with human cystic echinococcosis (CE) and alveolar echinococcosis (AE). 78 subjects including AE group (N = 28), CE group (N = 22), and healthy controls (HC, N = 28) were enrolled in this study. The mRNA expression levels of TLR2 and TLR4 in blood and hepatic tissue and plasma levels related cytokines were detected by using ELISA. Median levels of TLR2 mRNA in AE and CE groups were significantly elevated as compared with that in healthy control group. Median levels of TLR4 expression were increased in AE and CE. Plasma concentration levels of IL-5, IL-6, and IL-10 were slightly increased in AE and CE groups compared with those in HC group with no statistical differences (p > 0.05). The IL-23 concentration levels were significantly higher in AE and CE groups than that in HC subjects with statistical significance. The increased expression of TLR2 and IL-23 might play a potential role in modulating tissue infiltrative growth of the parasite and its persistence in the human host.
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