Evidence map›Paper›PMID 26635400›Full record

ArticleCirculation2016

National Trends in the Use of Cardiac Resynchronization Therapy With or Without Implantable Cardioverter-Defibrillator.

Charlotta Lindvall, Neal A Chatterjee, Yuchiao Chang, Betty Chernack, Vicki A Jackson, Jagmeet P Singh, Joshua P Metlay

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
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  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Long-term clinical outcomes of cardiac resynchronization therapy with or without defibrillation: impact of the aetiology of cardiomyopathy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2018
    Article
  18. Effect of battery longevity on costs and health outcomes associated with cardiac implantable electronic devices: a Markov model-based Monte Carlo simulation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2017
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Charlotta LindvallFrom Divisions of Palliative Care (C.L., V.A.J.), General Internal Medicine (C.L., Y.C., J.P.M.), and Cardiology (N.A.C., J.P.S.), Department of Medicine, Massachusetts General Hospital, Boston, MA and Harvard Medical School (C.L., Y.C., B.C., V.A.J., J.P.S., J.P.M.), Boston, MA. clindvall@mgh.harvard.edu.
Neal A ChatterjeeFrom Divisions of Palliative Care (C.L., V.A.J.), General Internal Medicine (C.L., Y.C., J.P.M.), and Cardiology (N.A.C., J.P.S.), Department of Medicine, Massachusetts General Hospital, Boston, MA and Harvard Medical School (C.L., Y.C., B.C., V.A.J., J.P.S., J.P.M.), Boston, MA.
Yuchiao ChangFrom Divisions of Palliative Care (C.L., V.A.J.), General Internal Medicine (C.L., Y.C., J.P.M.), and Cardiology (N.A.C., J.P.S.), Department of Medicine, Massachusetts General Hospital, Boston, MA and Harvard Medical School (C.L., Y.C., B.C., V.A.J., J.P.S., J.P.M.), Boston, MA.
Betty ChernackFrom Divisions of Palliative Care (C.L., V.A.J.), General Internal Medicine (C.L., Y.C., J.P.M.), and Cardiology (N.A.C., J.P.S.), Department of Medicine, Massachusetts General Hospital, Boston, MA and Harvard Medical School (C.L., Y.C., B.C., V.A.J., J.P.S., J.P.M.), Boston, MA.
Vicki A JacksonFrom Divisions of Palliative Care (C.L., V.A.J.), General Internal Medicine (C.L., Y.C., J.P.M.), and Cardiology (N.A.C., J.P.S.), Department of Medicine, Massachusetts General Hospital, Boston, MA and Harvard Medical School (C.L., Y.C., B.C., V.A.J., J.P.S., J.P.M.), Boston, MA.
Jagmeet P SinghFrom Divisions of Palliative Care (C.L., V.A.J.), General Internal Medicine (C.L., Y.C., J.P.M.), and Cardiology (N.A.C., J.P.S.), Department of Medicine, Massachusetts General Hospital, Boston, MA and Harvard Medical School (C.L., Y.C., B.C., V.A.J., J.P.S., J.P.M.), Boston, MA.
Joshua P MetlayFrom Divisions of Palliative Care (C.L., V.A.J.), General Internal Medicine (C.L., Y.C., J.P.M.), and Cardiology (N.A.C., J.P.S.), Department of Medicine, Massachusetts General Hospital, Boston, MA and Harvard Medical School (C.L., Y.C., B.C., V.A.J., J.P.S., J.P.M.), Boston, MA.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
NCATS NIH HHS UL1 TR001102
6 · The paper itself

Abstract

backgroundCandidates for cardiac resynchronization therapy (CRT) receive either a biventricular pacemaker or a biventricular pacemaker with an implantable cardioverter-defibrillator (CRT-D). Optimal device selection remains challenging because the benefit of implantable cardioverter-defibrillator therapy may not be uniform, particularly in patients at competing risk of nonsudden death. METHODS AND

resultsIn this serial cross-sectional study using the National Inpatient Sample database, we identified 311,086 admissions associated with CRT implant between 2006 to 2012. CRT-D was the most common device type (86.1%), including in patients ≥ 75 years of age with ≥ 5 Elixhauser comorbidities (75.5%). Multivariate predictors of CRT-D implant included demographic, clinical, and geographic factors: prior ventricular arrhythmia (rate ratio [RR], 1.14; 95% CI, 1.13-1.14), ischemic heart disease (RR, 1.11; 95% CI, 1.10-1.11), male sex (RR, 1.10; 95% CI, 1.09-1.10), black race (RR, 1.06; 95% CI: 1.04-1.07), and Northeast geographic region (RR, 1.06; 95% CI, 1.04-1.09). There was significant interhospital variation in the use of CRT-D (10-90 percentile range, 72.9%-98.0% CRT-D).

conclusionsThe majority of patients in this contemporary US cohort underwent implantation of CRT-D. Predictors of CRT-D implant included demographic, clinical, and geographic factors. In patient subgroups predicted to have an attenuated benefit from implantable cardioverter-defibrillator therapy (older adults with multiple comorbidities), CRT-D remained the dominant device type. An improved understanding of the determinants of device selection may aid in decision making and ultimately better align patient risk with device benefit at the time of CRT implantation.

Indexed as

AdolescentAdultAgedAged, 80 and overCardiac Resynchronization TherapyCohort StudiesCross-Sectional StudiesDefibrillators, ImplantableFemaleHumansMaleMiddle AgedUnited StatesYoung Adultcardiac resynchronization therapycardiac resynchronization therapy devicesdefibrillators, implantableelectric countershockheart failure

Identifiers

PMID26635400
PMCPMC5259807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.