ArticleNucleic acids research2016
RBP-Var: a database of functional variants involved in regulation mediated by RNA-binding proteins.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
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- RNA Modification-Related Genetic Variants in Genomic Loci Associated with Bone Mineral Density and Fracture.Genes · 2022Article
- N6-methyladenosine-related single-nucleotide polymorphism analyses identify oncogene RNFT2 in bladder cancer.Cancer cell international · 2022Article
- RNA modification-related variants in genomic loci associated with body mass index.Human genomics · 2022Article
- CircleBase: an integrated resource and analysis platform for human eccDNAs.Nucleic acids research · 2022Article
- A genome-wide association analysis: m6A-SNP related to the onset of oral ulcers.Frontiers in immunology · 2022Article
- RMDisease: a database of genetic variants that affect RNA modifications, with implications for epitranscriptome pathogenesis.Nucleic acids research · 2021Article
- RMVar: an updated database of functional variants involved in RNA modifications.Nucleic acids research · 2021Article
- Genetic variants in N6-methyladenosine are associated with bladder cancer risk in the Chinese population.Archives of toxicology · 2021Article
- Exploring Common Therapeutic Targets for Neurodegenerative Disorders Using Transcriptome Study.Frontiers in genetics · 2021Article
- Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses.Computational and structural biotechnology journal · 2021Article
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- AI-Driver: an ensemble method for identifying driver mutations in personal cancer genomes.NAR genomics and bioinformatics · 2020Article
- Role of m6A RNA methylation in cardiovascular disease (Review).International journal of molecular medicine · 2020Review
- Somatic mutations in colorectal cancer are associated with the epigenetic modifications.Journal of cellular and molecular medicine · 2020Article
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factors bind to the genome by forming specific contacts with the primary DNA sequence; however, RNA-binding proteins (RBPs) have greater scope to achieve binding specificity through the RNA secondary structure. It has been revealed that single nucleotide variants (SNVs) that alter RNA structure, also known as RiboSNitches, exhibit 3-fold greater local structure changes than replicates of the same DNA sequence, demonstrated by the fact that depletion of RiboSNitches could result in the alteration of specific RNA shapes at thousands of sites, including 3' UTRs, binding sites of microRNAs and RBPs. However, the network between SNVs and post-transcriptional regulation remains unclear. Here, we developed RBP-Var, a database freely available at http://www.rbp-var.biols.ac.cn/, which provides annotation of functional variants involved in post-transcriptional interaction and regulation. RBP-Var provides an easy-to-use web interface that allows users to rapidly find whether SNVs of interest can transform the secondary structure of RNA and identify RBPs whose binding may be subsequently disrupted. RBP-Var integrates DNA and RNA biology to understand how various genetic variants and post-transcriptional mechanisms cooperate to orchestrate gene expression. In summary, RBP-Var is useful in selecting candidate SNVs for further functional studies and exploring causal SNVs underlying human diseases.
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