ArticleScientific reports2015
Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verbana and its gut symbiont Aeromonas veronii.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Gut microbiota and metabolic function in leeches with distinct feeding niches.BMC microbiology · 2026Article
- Inhibition of Candida albicans yeast-to-hypha transition and virulence by cyclic dipeptides derived from probiotic Aeromonas veronii V03.Scientific reports · 2026Article
- Review
- Article
- Article
- Role of Antimicrobial Peptides in Immunity of Parasitic Leeches.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023Article
- Medicinal Leech Therapy in Urology: A PRISMA-Compliant Systematic Review.African journal of urology : the official journal of the Pan African Urological Surgeons' Association (PAUSA) · 2023Article
- Article
- Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex.Frontiers in microbiology · 2021Review
- The bacterioplankton community composition and a host genotype dependent occurrence of taxa shape the Daphnia magna gut bacterial community.FEMS microbiology ecology · 2020Article
- Antimicrobial Peptides and Ectosymbiotic Relationships: Involvement of a Novel Type IIa Crustin in the Life Cycle of a Deep-Sea Vent Shrimp.Frontiers in immunology · 2020Article
- Diet and Genotype of an Aquatic Invertebrate Affect the Composition of Free-Living Microbial Communities.Frontiers in microbiology · 2020Article
- Article
- Worms' Antimicrobial Peptides.Marine drugs · 2019Review
- Bacterial Community of the Digestive Tract of the European Medicinal Leech (Hirudo verbana) from the Danube River.Microbial ecology · 2019Article
- Functional Characterization of Probiotic Potential of Novel Pigmented Bacterial Strains for Aquaculture Applications.Probiotics and antimicrobial proteins · 2019Article
- Exploiting the Richness of Environmental Waterborne Bacterial Species to Find NaturalFrontiers in microbiology · 2018Article
- Instances of erroneous DNA barcoding of metazoan invertebrates: Are universal cox1 gene primers too "universal"?PloS one · 2018Article
- Host-genotype dependent gut microbiota drives zooplankton tolerance to toxic cyanobacteria.Nature communications · 2017Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The medicinal leech has established a long-term mutualistic association with Aeromonas veronii, a versatile bacterium which can also display free-living waterborne and fish- or human-pathogenic lifestyles. Here, we investigated the role of antibiotics in the dynamics of interaction between the leech and its gut symbiont Aeromonas. By combining biochemical and molecular approaches, we isolated and identified for the first time the antimicrobial peptides (AMPs) produced by the leech digestive tract and by its symbiont Aeromonas. Immunohistochemistry data and PCR analyses evidenced that leech AMP genes are induced in the gut epithelial cells when Aeromonas load is low (starved animals), while repressed when Aeromonas abundance is the highest (post blood feeding). The asynchronous production of AMPs by both partners suggests that these antibiotic substances (i) provide them with reciprocal protection against invasive bacteria and (ii) contribute to the unusual simplicity of the gut microflora of the leech. This immune benefit substantially reinforces the evidence of an evolutionarily stable association between H. verbana and A. veronii. Altogether these data may provide insights into the processes making the association with an Aeromonas species in the digestive tract either deleterious or beneficial.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.