ArticleScientific reports2015
Surgical Ventricular Entry is a Key Risk Factor for Leptomeningeal Metastasis of High Grade Gliomas.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Is leptomeningeal dissemination in oligodendroglioma predictable? Evidence from a scoping review.Frontiers in oncology · 2026Review
- Leptomeningeal metastases at recurrence in IDH-wildtype glioblastomas: incidence, risk factors, and prognosis based on postcontrast FLAIR imaging.European radiology · 2025Article
- The anatomic basis of leptomeningeal metastasis.The Journal of experimental medicine · 2024Review
- Article
- Supramaximal resection based on en-bloc technique reduces tumor burden and prolongs survival in primary supratentorial lobar glioblastoma.Journal of neuro-oncology · 2023Article
- Leptomeningeal Metastasis in Gliomas : Clinical Characteristics and Risk Factors.Journal of Korean Neurosurgical Society · 2023Article
- Cytokine Landscape in Central Nervous System Metastases.Biomedicines · 2022Review
- Machine Learning-Based Prediction of Lymph Node Metastasis Among Osteosarcoma Patients.Frontiers in oncology · 2022Article
- Efficacy of Whole-Ventricular Radiotherapy in Patients Undergoing Maximal Tumor Resection for Glioblastomas Involving the Ventricle.Frontiers in oncology · 2021Article
- Recurrent adult pilocytic astrocytoma presenting with intraventricular and leptomeningeal spread.Surgical neurology international · 2021Article
- Is local radiotherapy a viable option for patients with an opening of the ventricles during surgical resection of brain metastases?Radiation oncology (London, England) · 2020Article
- Leptomeningeal Spread in Glioblastoma: Diagnostic and Therapeutic Challenges.The oncologist · 2020Review
- Gliomatosis cerebri (GC) or GC-like? A picture to be reconsidered in neuro-oncology based on large retrospective analysis of GC series.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Extensive subdural spread of a glioblastoma associated with subdural hygroma: case report.Journal of surgical case reports · 2020Article
- Leptomeningeal dissemination of low-grade neuroepithelial CNS tumors in adults: a 15-year experience.Neuro-oncology practice · 2020Article
- Supratentorial high-grade astrocytoma with leptomeningeal spread to the fourth ventricle: a lethal dissemination with dismal prognosis.Journal of neuro-oncology · 2019Article
- Ventricular-Subventricular Zone Contact by Glioblastoma is Not Associated with Molecular Signatures in Bulk Tumor Data.Scientific reports · 2019Article
- Comparing Glioblastoma Surgery Decisions Between Teams Using Brain Maps of Tumor Locations, Biopsies, and Resections.JCO clinical cancer informatics · 2019Article
- Leptomeningeal Metastases.Current treatment options in oncology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptomeningeal metastasis (LM) of high grade gliomas (HGG) can lead to devastating disease courses. Understanding of risk factors for LM is important to identify patients at risk. We reviewed patient records and magnetic resonance imaging (MRI) of all patients with a first diagnosis of HGG who underwent surgery in our institution between 2008 and 2012. To assess the influence of potential risk factors for LM and the impact of LM on survival multivariate statistics were performed. 239 patients with a diagnosis of HGG and at least 6 months of MRI and clinical follow-up were included. LM occurred in 27 (11%) patients and was symptomatic in 17 (65%). A strong correlation of surgical entry to the ventricle and LM was found (HR: 8.1). Ventricular entry was documented in 137 patients (57%) and LM ensued in 25 (18%) of these. Only two (2%) of 102 patients without ventricular entry developed LM. Median overall survival of patients after diagnosis of LM (239 days) was significantly shorter compared to patients without LM (626 days). LM is a frequent complication in the course of disease of HGG and is associated with poor survival. Surgical entry to the ventricle is a key risk factor for LM.
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