Evidence map›Paper›PMID 26635108›Full record

ArticleHealth research policy and systems2015

Identifying potential indicators to measure the outcome of translational cancer research: a mixed methods approach.

Frédérique Thonon, Rym Boulkedid, Maria Teixeira, Serge Gottot, Mahasti Saghatchian, Corinne Alberti

Abstract read
In one paragraph

Article in Health research policy and systems, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Frédérique ThononEuropean and International Affairs Unit, Gustave Roussy, Villejuif, France. frederique.thonon@gustaveroussy.fr.
Rym BoulkedidAP-HP, Hôpital Robert Debré, Unité d'épidémiologie clinique, Paris, France. rym.boulkedid@aphp.fr.
Maria TeixeiraAP-HP, Hôpital Robert Debré, Unité d'épidémiologie clinique, Paris, France. maria.teixeira@aphp.fr.
Serge GottotAP-HP, Hôpital Robert Debré, Unité d'épidémiologie clinique, Paris, France. serge.gottot@rdb.aphp.fr.
Mahasti SaghatchianEuropean and International Affairs Unit, Gustave Roussy, Villejuif, France. mahasti.sagahtchian@gustaveroussy.fr.
Corinne AlbertiAP-HP, Hôpital Robert Debré, Unité d'épidémiologie clinique, Paris, France. corinne.alberti@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn a context where there is an increasing demand to evaluate the outcome of bio-medical research, our work aims to develop a set of indicators to measure the impact of translational cancer research. The objective of our study was to explore the scope and issues of translational research relevant to evaluation, explore the views of researchers on the evaluation of oncological translational research, and select indicators measuring the outcomes and outputs of translational research in oncology by consensus.

methodsSemi-structured interviews amongst 23 researchers involved in translational cancer research were conducted and analysed using thematic analysis. A two-round modified Delphi survey of 35 participants with similar characteristics was then performed followed by a physical meeting. Participants rated the feasibility and validity of 60 indicators. The physical meeting was held to discuss the methodology of the new indicators.

resultsThe main themes emerging from the interviews included a common definition for translational research but disagreements about the exact scope and limits of this research, the importance of multidisciplinarity and collaboration for the success of translational research, the disadvantages that translational research faces in current evaluation systems, the relative lack of pertinence of existing indicators, and propositions to measure translational cancer research in terms of clinical applications and patient outcomes. A total of 35 participants took part in the first round survey and 12 in the second round. The two-round survey helped us select a set of 18 indicators, including four that seemed to be particularly adapted to measure translational cancer research impact on health service research (number of biomarkers identified, generation of clinical guidelines, citation of research in clinical guidelines, and citation of research in public health guidelines). The feedback from participants helped refine the methodology and definition of indicators not commonly used.

conclusionIndicators need to be accepted by stakeholders under evaluation. This study helped the selection and refinement of indicators considered as the most relevant by researchers in translational cancer research. The feasibility and validity of those indicators will be tested in a scientometric study.

Indexed as

ConsensusNeoplasmsProcess Assessment, Health CareQuality Indicators, Health CareTranslational Research, BiomedicalAdultAttitude of Health PersonnelBiomedical ResearchClinical ProtocolsFemaleHealth Services ResearchHumansMaleResearch PersonnelSurveys and Questionnaires

Identifiers

PMID26635108
PMCPMC4669638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.