ArticleBMC genetics2015
A genome-wide association study of asthma symptoms in Latin American children.
Article in BMC genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Genome-wide burden and association analyses implicate copy number variations in asthma risk among children and young adults from Latin America.Scientific reports · 2018Trial
- Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.Clinical and translational allergy · 2023Review
- Assessing the prevalence and severity of asthma, rhinitis, and eczema among schoolchildren (6-7 and 13-14 years old) in Khuzestan, Iran: a cross-sectional survey.BMC pediatrics · 2022Article
- Transcriptome-Wide m6A Methylome and m6A-Modified Gene Analysis in Asthma.Frontiers in cell and developmental biology · 2022Article
- Article
- Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD.The European respiratory journal · 2020Article
- Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Reconstructing recent population history while mapping rare variants using haplotypes.Scientific reports · 2019Article
- Food Consumption as a Modifier of the Association betweenNutrients · 2018Article
- Multiobjective grammar-based genetic programming applied to the study of asthma and allergy epidemiology.BMC bioinformatics · 2018Article
- Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children.European journal of human genetics : EJHG · 2017Article
- Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children.PloS one · 2017Article
- Quality of Life of asthmatic children and their caregivers.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
24 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAsthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population.
methods1246 children were recruited from a longitudinal cohort study in Salvador, Brazil. Asthma symptoms were identified in accordance with an International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Following quality control, 1,877,526 autosomal SNPs were tested for association with childhood asthma symptoms by logistic regression using an additive genetic model. We complemented the analysis with an estimate of the phenotypic variance explained by common genetic variants. Replications were investigated in independent Mexican and US Latino samples.
resultsTwo chromosomal regions reached genome-wide significance level for childhood asthma symptoms: the 14q11 region flanking the DAD1 and OXA1L genes (rs1999071, MAF 0.32, OR 1.78, 95% CI 1.45-2.18, p-value 2.83 × 10(-8)) and 15q22 region flanking the FOXB1 gene (rs10519031, MAF 0.04, OR 3.0, 95% CI 2.02-4.49, p-value 6.68 × 10(-8) and rs8029377, MAF 0.03, OR 2.49, 95% CI 1.76-3.53, p-value 2.45 × 10(-7)). eQTL analysis suggests that rs1999071 regulates the expression of OXA1L gene. However, the original findings were not replicated in the Mexican or US Latino samples.
conclusionsWe conclude that the 14q11 and 15q22 regions may be associated with asthma symptoms in childhood.
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