ArticleArthritis research & therapy2015
Discovery of a novel genetic susceptibility locus on X chromosome for systemic lupus erythematosus.
Article in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07476404 (Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch (HES) Fluid Therapy: A Retrospective Cohort Study
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- A systematic review of analytical methods used in genetic association analysis of the X-chromosome.Briefings in bioinformatics · 2022Pooled it
- Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.Arthritis research & therapy · 2018Pooled it
- Proxy-reported health-related quality of life of children with systemic lupus erythematosus and well-being of caregivers: a cross-sectional survey among caregivers in China.European journal of pediatrics · 2024Article
- The 330 risk loci known for systemic lupus erythematosus (SLE): a review.Frontiers in lupus · 2024Article
- Exploring the transcriptomic landscape of moyamoya disease and systemic lupus erythematosus: insights into crosstalk genes and immune relationships.Frontiers in immunology · 2024Article
- An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2023Article
- Abnormally high expression of D1-like dopamine receptors on lupus CD4Lupus science & medicine · 2023Article
- X-Chromosome Inactivation and Related Diseases.Genetics research · 2022Review
- Article
- X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma.Biology of sex differences · 2019Article
- GWAS Follow-up Study Discovers a Novel Genetic Signal on 10q21.2 for Atopic Dermatitis in Chinese Han Population.Frontiers in genetics · 2019Article
- Elevated expression of miR-142-3p is related to the pro-inflammatory function of monocyte-derived dendritic cells in SLE.Arthritis research & therapy · 2016Article
- A long non-coding RNA signature to improve prognosis prediction of gastric cancer.Molecular cancer · 2016Article
- Pattern of initial clinical manifestations of systemic lupus erythematosus in a tertiary care hospital.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
31 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSystemic lupus erythematosus (SLE) is an autoimmune connective tissue disease affecting predominantly females. To discover additional genetic risk variants for SLE on the X chromosome, we performed a follow-up study of our previously published genome-wide association study (GWAS) data set in this study.
methodsTwelve single nucleotide polymorphisms (SNPs) within novel or unpublished loci with P-value < 1.00 × 10(-02) were selected for genotype with a total of 2,442 cases and 2,798 controls(including 1,156 cases and 2,330 controls from central China, 1,012 cases and 335 controls from southern China and 274 cases and 133 controls from northern China) using Sequenom Massarry system. Associaton analyses were performed using logistic regression with sample region as a covariate through PLINK 1.07 software.
resultsCombined analysis in discovery and central validation dataset discovered a novel locus rs5914778 within LINC01420 associated with SLE at genome-wide significance (P = 1.00 × 10(-08); odds ratio (OR) = 1.32). We also confirmed rs5914778 in the southern Chinese sample cohort (P = 5.31 × 10(-05); OR = 1.51), and meta-analysis of the samples from the discovery, central and southern validations regions provided robust evidence for the association of rs5914778 (P = 5.26 × 10(-12); OR = 1.35). However, this SNP did not show association with SLE in the northern sample (P = 0.33). Further analysis represent the association of northern was significantly heterogeneous compared to central and southern respectively.
conclusionsOur study increases the number of established susceptibility loci for SLE in Han Chinese population and has further demonstrated the important role of X-linked genetic risk variants in the pathogenesis of SLE in Chinese Han population.
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