ArticleNature communications2015
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
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Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 8 of them syntheses that pooled it.
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76citing papers in PubMed, 8 pooled it
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Who cites it
76 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.The American journal of clinical nutrition · 2024Pooled it
- Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.Nature genetics · 2023Pooled it
- X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.Respiratory research · 2023Pooled it
- Genetic association and causal inference between lung function and venous thromboembolism.Respiratory research · 2023Pooled it
- Genome-wide association studies of exacerbations in children using long-acting beta2-agonists.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Pooled it
- Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.Nature communications · 2018Pooled it
- Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.Nature genetics · 2017Pooled it
- Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects.American journal of respiratory cell and molecular biology · 2017Pooled it
- Gene network approach reveals co-expression patterns in nasal and bronchial epithelium.Scientific reports · 2019Trial
- Genetic Susceptibility to Impaired Lung Function in Underground Coal Miners from Kazakhstan.Genes · 2026Article
- Observational
- Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.Genome biology · 2026Article
- HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma.Communications biology · 2025Article
- Genomic Locus Tagged by Lung Function GWAS SNV rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Characterisation of a COPD-associated nephronectin (The European respiratory journal · 2025Article
- STLBRF: an improved random forest algorithm based on standardized-threshold for feature screening of gene expression data.Briefings in functional genomics · 2025Article
- Novel reporter systems to detect cold and osmotic stress responses.Biology methods & protocols · 2025Article
- Multivariable MR Can Mitigate Bias in Two-Sample MR Using Covariable-Adjusted Summary Associations.Genetic epidemiology · 2025Article
- Lung function and nonalcoholic fatty liver disease: a Mendelian randomization study.Archives of medical science : AMS · 2025Article
- Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024Review
16 more citing papers are in PubMed but not listed here.
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Authors and funding
91 authors.
María Soler ArtigasGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
Louise V WainGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
Suzanne MillerDivision of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK.
Abdul Kader KheirallahDivision of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK.
Jennifer E HuffmanMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
Ioanna NtallaGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
Nick ShrineGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
Ma'en ObeidatUniversity of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada V6Z 1Y6.
Holly TrochetMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
Alexessander Couto AlvesDepartment of Epidemiology and Biostatistics, MRC -PHE Centre for Environment &Health, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Jennie HuiBusselton Population Medical Research Institute, Busselton, Western Australia 6280, Australia.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Peter K JoshiUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AD, Scotland, UK.
Alexander TeumerUniversity Medicine Greifswald, Community Medicine, SHIP-Clinical Epidemiological Research, Greifswald 17489, Germany.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Medea ImbodenSwiss Tropical and Public Health Institute, Basel 4051, Switzerland.
Rajesh RawalInstitute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Lorna M LopezCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9AD, UK.
Jonathan MartenMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
Stefan EnrothDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala 751 23, Sweden.
Ida SurakkaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Ozren PolasekUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AD, Scotland, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere FI-33101, Finland.
Raquel GranellSchool of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
Pirro G HysiKCL Department of Twins Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
Claudia FlexederInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
John BeilbyBusselton Population Medical Research Institute, Busselton, Western Australia 6280, Australia.
Yohan BosséDepartment of Molecular Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada G1V 0A6.
Corry-Anke BrandsmaDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen 9700, The Netherlands.
Harry CampbellUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AD, Scotland, UK.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Sven GläserDepartment of Internal Medicine B, Pneumology, Cardiology, Intensive Care, Weaning, Field of Research: Pneumological Epidemiology, University Medicine Greifswald, Greifswald 17489, Germany.
Juan R GonzálezCentre for Research in Environmental Epidemiology (CREAL), Barcelona E-08003, Spain.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Chris J HammondKCL Department of Twins Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9AD, UK.
Anna-Liisa HartikainenDepartment of Obstetrics and Gynecology of Oulu University Hospital ,MRC of Oulu University, Oulu 90220, Finland.
Markku HeliövaaraThe National Institute for Health and Welfare (THL), Helsinki FI-00271, Finland.
John HendersonSchool of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
Lynne HockingGeneration Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh, Glasgow EH4 2XU, UK.
Momoko HorikoshiWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University Hospital, Tampere 33521, Finland.
Erik IngelssonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Åsa JohanssonDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala 751 23, Sweden.
John P KempSchool of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
Ashish KumarSwiss Tropical and Public Health Institute, Basel 4051, Switzerland.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala 751 23, Sweden.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet and Sachs' Children's Hospital, Stockholm SE-171 7, Sweden.
Arthur W MuskBusselton Population Medical Research Institute, Busselton, Western Australia 6280, Australia.
Pau NavarroMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
David C NickleGenetics and Pharmacogenomics, Merck Research Labs, Boston, Massachusetts 02115, USA.
Sandosh PadmanabhanGeneration Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh, Glasgow EH4 2XU, UK.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20520, Finland.
Janina S RiedInstitute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014, Finland.
Holger SchulzInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Don D SinUniversity of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada V6Z 1Y6.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9AD, UK.
UK BiLEVE
Ana ViñuelaKCL Department of Twins Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
Henry VölzkeUniversity Medicine Greifswald, Community Medicine, SHIP-Clinical Epidemiological Research, Greifswald 17489, Germany.
Sarah H WildUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AD, Scotland, UK.
Alan F WrightMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
Tatijana ZemunikDepartment of Medical Biology, Faculty of Medicine, University of Split, Split 21000, Croatia.
Deborah L JarvisRespiratory Epidemiology and Public Health, Imperial College London, London SW7 2AZ, UK.
Tim D SpectorKCL Department of Twins Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
David M EvansSchool of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere FI-33101, Finland.
Veronique VitartMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
Mika KähönenDepartment of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere 33521, Finland.
Ulf GyllenstenDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala 751 23, Sweden.
Igor RudanUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AD, Scotland, UK.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9AD, UK.
Stefan KarraschInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Nicole M Probst-HenschSwiss Tropical and Public Health Institute, Basel 4051, Switzerland.
Joachim HeinrichInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg D-85764, Germany.
Beate StubbeDepartment of Internal Medicine B, Pneumology, Cardiology, Intensive Care, Weaning, Field of Research: Pneumological Epidemiology, University Medicine Greifswald, Greifswald 17489, Germany.
James F WilsonMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland EH8 9AD, UK.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0SL, UK.
Alan L JamesBusselton Population Medical Research Institute, Busselton, Western Australia 6280, Australia.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC -PHE Centre for Environment &Health, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Caroline HaywardGeneration Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh, Glasgow EH4 2XU, UK.
Ian SayersDivision of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK.
David P StrachanPopulation Health Research Institute, St George's, University of London, Cranmer Terrace, London WC1B 5DN, UK.
Ian P HallDivision of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK.
Martin D TobinGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
Funding
Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MGenetics of cardiovascular risk factors in large founder population birth controlR01HL087679 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HIRSCHHORN, JOEL N · 2007 to 2009
$4.0MGenetic Influences on ADHD in a Finnish Birth CohortR01MH063706 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALLEY, SUSAN L · 2001 to 2005
$3.3MWhole Genome Assoc. Analysis Strategies for Multi. PhenotypesRL1MH083268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$2.1MInternational Collaborative Twin Study of Refractive and Glaucoma EndophenotypesR01EY018246 · NEI · DUKE UNIVERSITY · PI YOUNG, TERRI LOIS · 2007 to 2009
$1.8MBiotechnology and Biological Sciences Research Council BB/F019394/1Chief Scientist Office CZB/4/505Chief Scientist Office CZD/16/6/4Chief Scientist Office ETM/55Department of Health SRF/01/010Medical Research Council G0000934Medical Research Council G0500539Medical Research Council G0501942Medical Research Council G0600705Medical Research Council G0902313Medical Research Council G1000861Medical Research Council G1001799Medical Research Council G1002319Medical Research Council MC_PC_12010Medical Research Council MC_PC_U127561128Medical Research Council MC_PC_U127592696Medical Research Council MC_U106179471Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12015/1Medical Research Council MR/K026992/1Medical Research Council MR/L01341X/1Medical Research Council MR/N01104X/1NEI NIH HHS 1R01EY018246NEI NIH HHS R01 EY018246NHLBI NIH HHS 5R01HL087679-02NHLBI NIH HHS R01 HL087679NIDDK NIH HHS U01 DK062418NIMH NIH HHS 1RL1MH083268-01NIMH NIH HHS 5R01MH63706:02NIMH NIH HHS R01 MH063706NIMH NIH HHS RL1 MH083268Wellcome Trust 068545/Z/02Wellcome Trust 076113/B/04/ZWellcome Trust 079895Wellcome Trust 092731Wellcome Trust 098017Wellcome Trust WT064890Wellcome Trust WT 084703MAWellcome Trust WT090532
Abstract
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Indexed as
Genome-Wide Association StudyAdultAgedAged, 80 and overFemaleForced Expiratory VolumeHumansLungLung DiseasesMaleMiddle AgedPolymorphism, Single NucleotideWhite PeopleYoung Adult
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