ArticlePlant physiology2016
Arabidopsis CML38, a Calcium Sensor That Localizes to Ribonucleoprotein Complexes under Hypoxia Stress.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 105 citations in OpenAlex.
- TheInternational journal of molecular sciences · 2026Article
- Flooding-induced transcriptomic responses and yield stability in oil palm (Elaeis guineensis).Planta · 2026Article
- Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Discrete and cell-specific hypoxic responses in Arabidopsis roots resolved by single-nuclei transcriptomics.The New phytologist · 2026Article
- The role of plant metacaspases in cell death and survival.Cell death and differentiation · 2026Review
- Translational control in plants: from basic mechanisms to environmental and developmental responses.The Plant journal : for cell and molecular biology · 2026Review
- The role of post-translational modifications in the dynamics of cytoplasmic biomolecular condensates in plants.The New phytologist · 2025Review
- Article
- Can autophagy enhance crop resilience to environmental stress?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Principles of signal integration in combinatorial stress acclimatization.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Transcriptome Analysis of thePlants (Basel, Switzerland) · 2025Article
- CML38 is involved in NO-induced inhibition of hypocotyl elongation in Arabidopsis.Frontiers in plant science · 2025Article
- CINV1 and CINV2 are required for increased tolerance to diverse stresses after ethylene-pretreatment of germinating seeds.PloS one · 2025Article
- A review of soil waterlogging impacts, mechanisms, and adaptive strategies.Frontiers in plant science · 2025Review
- Primed to persevere: Hypoxia regulation from epigenome to protein accumulation in plants.Plant physiology · 2024Review
- The calcium-dependent protein kinase CPK16 regulates hypoxia-induced ROS production by phosphorylating the NADPH oxidase RBOHD in Arabidopsis.The Plant cell · 2024Article
- Detection of Stress-Induced Changes in Subcellular Protein Distribution.Methods in molecular biology (Clifton, N.J.) · 2024Article
- CPK12 and CaPlant signaling & behavior · 2023Article
- Finding Balance in Adversity: Nitrate Signaling as the Key to Plant Growth, Resilience, and Stress Response.International journal of molecular sciences · 2023Review
- Calcium signaling-mediated transcriptional reprogramming during abiotic stress response in plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
6 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During waterlogging and the associated oxygen deprivation stress, plants respond by the induction of adaptive programs, including the redirected expression of gene networks toward the synthesis of core hypoxia-response proteins. Among these core response proteins in Arabidopsis (Arabidopsis thaliana) is the calcium sensor CML38, a protein related to regulator of gene silencing calmodulin-like proteins (rgsCaMs). CML38 transcripts are up-regulated more than 300-fold in roots within 6 h of hypoxia treatment. Transfer DNA insertional mutants of CML38 show an enhanced sensitivity to hypoxia stress, with lowered survival and more severe inhibition of root and shoot growth. By using yellow fluorescent protein (YFP) translational fusions, CML38 protein was found to be localized to cytosolic granule structures similar in morphology to hypoxia-induced stress granules. Immunoprecipitation of CML38 from the roots of hypoxia-challenged transgenic plants harboring CML38pro::CML38:YFP followed by liquid chromatography-tandem mass spectrometry analysis revealed the presence of protein targets associated with messenger RNA ribonucleoprotein (mRNP) complexes including stress granules, which are known to accumulate as messenger RNA storage and triage centers during hypoxia. This finding is further supported by the colocalization of CML38 with the mRNP stress granule marker RNA Binding Protein 47 (RBP47) upon cotransfection of Nicotiana benthamiana leaves. Ruthenium Red treatment results in the loss of CML38 signal in cytosolic granules, suggesting that calcium is necessary for stress granule association. These results confirm that CML38 is a core hypoxia response calcium sensor protein and suggest that it serves as a potential calcium signaling target within stress granules and other mRNPs that accumulate during flooding stress responses.
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