ArticleScientific reports2015
Secretome identification of immune cell factors mediating metastatic cell homing.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Cracking the Codes behind Cancer Cells' Immune Evasion.International journal of molecular sciences · 2024Review
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- Dynamic Endothelial Stalk Cell-Matrix Interactions Regulate Angiogenic Sprout Diameter.Frontiers in bioengineering and biotechnology · 2021Article
- Article
- Engineered Niches to Analyze Mechanisms of Metastasis and Guide Precision Medicine.Cancer research · 2020Review
- Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo.Biotechnology and bioengineering · 2020Article
- High Frequency Spectral Ultrasound Imaging to Detect Metastasis in Implanted Biomaterial Scaffolds.Annals of biomedical engineering · 2020Article
- Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation.Science translational medicine · 2019Article
- Biomaterial Scaffolds Recruit an Aggressive Population of Metastatic Tumor CellsCancer research · 2019Article
- Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells.Nature biomedical engineering · 2018Article
- Biomaterials to model and measure epithelial cancers.Nature reviews. Materials · 2018Article
- Synergy of Paracrine Signaling During Early-Stage Mouse Ovarian Follicle DevelopmentCellular and molecular bioengineering · 2018Article
- Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment.Advanced healthcare materials · 2018Article
- Engineering the pre-metastatic niche.Nature biomedical engineering · 2017Article
- Extracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche.Acta biomaterialia · 2016Article
- Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.The Journal of cell biology · 2016Article
- Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma.American journal of cancer research · 2016Article
- Differential Expression Pattern of THBS1 and THBS2 in Lung Cancer: Clinical Outcome and a Systematic-Analysis of Microarray Databases.PloS one · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
Metastatic cell homing is a complex process mediated in part by diffusible factors secreted from immune cells found at a pre-metastatic niche. We report on connecting secretomics and TRanscriptional Activity CEll aRray (TRACER) data to identify functional paracrine interactions between immune cells and metastatic cells as novel mediators of homing. Metastatic breast cancer mouse models were used to generate a diseased splenocyte conditioned media (D-SCM) containing immune cell secreted factors. MDA-MB-231 metastatic cell activity including cell invasion, migration, transendothelial migration, and proliferation were increased in D-SCM relative to control media. Our D-SCM secretome analysis yielded 144 secreted factor candidates that contribute to increased metastatic cell activity. The functional mediators of homing were identified using MetaCore software to determine interactions between the immune cell secretome and the TRACER-identified active transcription factors within metastatic cells. Among the 5 candidate homing factors identified, haptoglobin was selected and validated in vitro and in vivo as a key mediator of homing. Our studies demonstrate a novel systems biology approach to identify functional signaling factors associated with a cellular phenotype, which provides an enabling tool that complements large-scale protein identification provided by proteomics.
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