Evidence map›Paper›PMID 26634886›Full record

ArticleHIV medicine2016

Carotid artery thickness is associated with chronic use of highly active antiretroviral therapy in patients infected with human immunodeficiency virus: A 3.0 Tesla magnetic resonance imaging study.

T M LaBounty, W D Hardy, Z Fan, R Yumul, D Li, R Dharmakumar, A Hernandez Conte

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

T M LaBountyDepartments of Medicine and Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA.
W D HardyDavid Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Z FanBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
R YumulDepartment of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
D LiBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
R DharmakumarBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
A Hernandez ConteDepartment of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · USUniversity of California, Los Angeles · USUniversity of Michigan–Ann Arbor · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Flow Sensitive SSFP for Non-Contrast MRA and Vessel Wall ImagingR01HL096119 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LI, DEBIAO · 2009 to 2018
$3.3M
NCATS NIH HHS UL1 TR000124NHLBI NIH HHS R01 HL096119
6 · The paper itself

Abstract

objectivesWhile patients with HIV infection have an elevated stroke risk, ultrasound studies of carotid artery wall thickness have reported variable results. We hypothesized that subjects with HIV infection on chronic highly active antiretroviral therapy (HAART) would have increased carotid artery wall thickness by magnetic resonance imaging (MRI).

methodsThis cross-sectional study compared carotid artery wall thickness between 26 individuals infected with HIV on chronic HAART and 20 controls, without HIV infection but with similar cardiovascular risk factors, using 3.0-T noncontrast MRI. Inclusion criteria included male gender, age 35-55 years, and chronic HAART (≥ 3 years) among HIV-seropositive subjects; those with known cardiovascular disease or diabetes were excluded.

resultsBetween subjects with HIV infection and controls, there were no differences in mean (±SD) age (47.8 ± 5.0 vs. 47.8 ± 4.7 years, respectively; P = 0.19) or cardiovascular risk factors (P > 0.05 for each). Mean (±SD) wall thickness was increased in those with HIV infection vs. controls for the left (0.88 ± 0.08 vs. 0.83 ± 0.08 mm, respectively; P = 0.03) and right (0.90 ± 0.10 vs. 0.85 ± 0.07 mm, respectively; P = 0.046) common carotid arteries. Among individuals with HIV infection, variables associated with increased mean carotid artery wall thickness included lipoaccumulation [+0.09 mm; 95% confidence interval (CI) 0.03-0.14 mm; P = 0.003], Framingham risk score ≥ 5% (+0.07 mm; 95% CI 0.01-0.12; P = 0.02 mm), and increased duration of protease inhibitor therapy (+0.03 mm per 5 years; 95% CI 0.01-0.06 mm; P = 0.02).

conclusionsIndividuals with HIV infection on chronic HAART had increased carotid artery wall thickness as compared to similar controls. In subjects with HIV infection, the presence of lipoaccumulation and longer duration of protease inhibitor therapy were associated with greater wall thickness.

Indexed as

Antiretroviral Therapy, Highly ActiveMagnetic Resonance ImagingAdultAnti-Retroviral AgentsCarotid ArteriesCross-Sectional StudiesHIV InfectionsHumansMaleMiddle AgedAnti-Retroviral Agentscarotid artery diseasehighly active antiretroviral therapyHIVmagnetic resonance imagingstroke

Identifiers

PMID26634886
PMCPMC5477634
OpenAlexW2186226605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.